4ddf: Difference between revisions
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==Computationally Designed Self-assembling Octahedral Cage protein, O333, Crystallized in space group P4== | |||
<StructureSection load='4ddf' size='340' side='right'caption='[[4ddf]], [[Resolution|resolution]] 3.15Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4ddf]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica Salmonella enterica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DDF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DDF FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.15Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ddf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ddf OCA], [https://pdbe.org/4ddf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ddf RCSB], [https://www.ebi.ac.uk/pdbsum/4ddf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ddf ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PDUT_SALTY PDUT_SALTY] A minor shell protein of the bacterial microcompartment (BMC) dedicated to 1,2-propanediol (1,2-PD) degradation. The isolated BMC shell component protein ratio for J:A:B':B:K:T:U is approximately 15:10:7:6:1:1:2 (PubMed:12923081). Not required for structural integrity of BMCs nor to mitigate propionaldehyde toxicity, may selectively transport specific metabolites (PubMed:21239588). May be involved in electron transport across the BMC shell (Probable). Can be engineered to alter permeability of the BMC shell (PubMed:31674899).<ref>PMID:12923081</ref> <ref>PMID:21239588</ref> <ref>PMID:31674899</ref> <ref>PMID:20870711</ref> The 1,2-PD-specific bacterial microcompartment (BMC) concentrates low levels of 1,2-PD catabolic enzymes, concentrates volatile reaction intermediates thus enhancing pathway flux and keeps the level of toxic, mutagenic propionaldehyde low.<ref>PMID:28475631</ref> | |||
== References == | |||
== | <references/> | ||
[[4ddf]] is a 12 chain structure with sequence from [ | __TOC__ | ||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Salmonella enterica]] | [[Category: Salmonella enterica]] | ||
[[Category: Baker | [[Category: Baker D]] | ||
[[Category: King | [[Category: King NP]] | ||
[[Category: Sawaya | [[Category: Sawaya MR]] | ||
[[Category: Sheffler | [[Category: Sheffler W]] | ||
[[Category: Yeates | [[Category: Yeates TO]] | ||
Latest revision as of 10:44, 1 March 2024
Computationally Designed Self-assembling Octahedral Cage protein, O333, Crystallized in space group P4
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