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[[Image:1yln.png|left|200px]]


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==The Crystal Structure of the Protein of Unknown Function VCA0042 from Vibrio cholerae O1==
The line below this paragraph, containing "STRUCTURE_1yln", creates the "Structure Box" on the page.
<StructureSection load='1yln' size='340' side='right'caption='[[1yln]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1yln]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae_O1 Vibrio cholerae O1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YLN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YLN FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OSE:O-SULFO-L-SERINE'>OSE</scene></td></tr>
{{STRUCTURE_1yln|  PDB=1yln  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yln FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yln OCA], [https://pdbe.org/1yln PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yln RCSB], [https://www.ebi.ac.uk/pdbsum/1yln PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yln ProSAT], [https://www.topsan.org/Proteins/MCSG/1yln TOPSAN]</span></td></tr>
 
</table>
===The Crystal Structure of the Protein of Unknown Function VCA0042 from Vibrio cholerae O1===
== Function ==
 
[https://www.uniprot.org/uniprot/YCGRL_VIBCH YCGRL_VIBCH] May act as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)-dependent manner. Increasing levels of c-di-GMP lead to decreased motility (Potential). Binds bis-(3'-5') cyclic diguanylic acid (c-di-GMP) with a dissociation constant of 170 nM in the presence of 10 mM KCl and with 100 nM in its absence. Binds 1 to 2 c-di-GMP per subunit. Only 1 c-di-GMP is seen in the wild-type crystal, while 2 are seen in the mutant. Depending on the concentration of K(+) stoichiometries of 1:1, 1.43:1 and 2:1 are determined by isothermal titration calorimetry.
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
[[1yln]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae_o1 Vibrio cholerae o1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YLN OCA].  
Check<jmol>
 
  <jmolCheckbox>
==See Also==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yl/1yln_consurf.spt"</scriptWhenChecked>
*[[C-di-GMP receptors with PilZ domain|C-di-GMP receptors with PilZ domain]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
[[Category: Vibrio cholerae o1]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Collart, F.]]
  </jmolCheckbox>
[[Category: Joachimiak, A.]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yln ConSurf].
[[Category: MCSG, Midwest Center for Structural Genomics.]]
<div style="clear:both"></div>
[[Category: Moy, S.]]
__TOC__
[[Category: Zhang, R.]]
</StructureSection>
[[Category: Zhou, M.]]
[[Category: Large Structures]]
[[Category: Beta barrel]]
[[Category: Vibrio cholerae O1]]
[[Category: Mcsg]]
[[Category: Collart F]]
[[Category: Midwest center for structural genomic]]
[[Category: Joachimiak A]]
[[Category: Protein structure initiative]]
[[Category: Moy S]]
[[Category: Psi]]
[[Category: Zhang R]]
[[Category: Structural genomic]]
[[Category: Zhou M]]
[[Category: Unknown function]]
[[Category: Vibrio cholerae o1]]
Retrieved from "https://proteopedia.org/1yln"