Foxp2 bound specifically to DNA: Difference between revisions
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<StructureSection load='2a07' size='350' side='right' scene= caption='Forkhead box protein 2 complex with DNA (PDB code [[2a07]])'> | |||
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==Introduction== | ==Introduction== | ||
(see also [[FOXP2]])<br> | (see also [[FOXP2]], [[Transcription & RNA Processing]], and [[Regulation of Gene Expression]])<br> | ||
FOXP2 is a transcription factor containing a winged-helix DNA binding domain, and is necessary for proper development of the lungs and brain. It is located on human chromosome 7 (7q31), and comprises 715 amino acids in its major splice form. FOXP2 is a member of the FOX (forkhead box) family and FOXP (FOXP1-4) subfamily of proteins, all of which contain a 90 amino acid winged-helix DNA binding motif. The foxP subfamily contains motifs like a glutamine-rich region, a leucine zipper, a zinc finger, and a forkhead domain, and is notable for conducting domain swapping.<br><br> | FOXP2 is a transcription factor containing a winged-helix DNA binding domain, and is necessary for proper development of the lungs and brain. It is located on human chromosome 7 (7q31), and comprises 715 amino acids in its major splice form. FOXP2 is a member of the FOX (forkhead box) family and FOXP (FOXP1-4) subfamily of proteins, all of which contain a 90 amino acid winged-helix DNA binding motif. The foxP subfamily contains motifs like a glutamine-rich region, a leucine zipper, a zinc finger, and a forkhead domain, and is notable for conducting domain swapping.<br><br> | ||
==About this Structure== | ==About this Structure== | ||
[[2a07]] is a 10 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A07 OCA]. | |||
==Evolutionary Conservation== | ==Evolutionary Conservation== | ||
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==External Links== | ==External Links== | ||
[http://en.wikipedia.org/wiki/FOXP2] Wikipedia FoxP2 entry | [http://en.wikipedia.org/wiki/FOXP2] Wikipedia FoxP2 entry | ||
</StructureSection> | |||
==References== | ==References== | ||
