4dey: Difference between revisions

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[[Image:4dey.jpg|left|200px]]


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==Crystal structure of the Voltage Dependent Calcium Channel beta-2 Subunit in Complex With The CaV1.2 I-II Linker.==
The line below this paragraph, containing "STRUCTURE_4dey", creates the "Structure Box" on the page.
<StructureSection load='4dey' size='340' side='right'caption='[[4dey]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[4dey]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DEY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DEY FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>
{{STRUCTURE_4dey|  PDB=4dey  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dey FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dey OCA], [https://pdbe.org/4dey PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dey RCSB], [https://www.ebi.ac.uk/pdbsum/4dey PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dey ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CAC1C_RABIT CAC1C_RABIT] Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function (By similarity).


===Crystal structure of the Voltage Dependent Calcium Channel beta-2 Subunit in Complex With The CaV1.2 I-II Linker.===
==See Also==
 
*[[Ion channels 3D structures|Ion channels 3D structures]]
 
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_22649239}}
 
==About this Structure==
[[4dey]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DEY OCA].
 
==Reference==
<ref group="xtra">PMID:022649239</ref><references group="xtra"/>
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
[[Category: Almagor, L.]]
[[Category: Almagor L]]
[[Category: Hirsch, J A.]]
[[Category: Hirsch JA]]
[[Category: Maguk]]
[[Category: Transport protein]]
[[Category: Voltage dependent calcium channel]]
Retrieved from "https://proteopedia.org/4dey"