4a6h: Difference between revisions

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[[Image:4a6h.jpg|left|200px]]


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==Crystal structure of Slm1-PH domain in complex with Inositol-4- phosphate==
The line below this paragraph, containing "STRUCTURE_4a6h", creates the "Structure Box" on the page.
<StructureSection load='4a6h' size='340' side='right'caption='[[4a6h]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[4a6h]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A6H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A6H FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.449&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I4D:D-MYO-INOSITOL-4-PHOSPHATE'>I4D</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
{{STRUCTURE_4a6h|  PDB=4a6h  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a6h OCA], [https://pdbe.org/4a6h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a6h RCSB], [https://www.ebi.ac.uk/pdbsum/4a6h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a6h ProSAT]</span></td></tr>
 
</table>
===Crystal structure of Slm1-PH domain in complex with Inositol-4- phosphate===
== Function ==
 
[https://www.uniprot.org/uniprot/SLM1_YEAST SLM1_YEAST] Together with SLM2, effector of the TORC2- and calcineurin-signaling pathways. Phosphorylated and activated by TORC2 under favorable growth conditions. Mediates actin polarization via inhibition of calcineurin-dependent transcription. Upon nutrient limitation or environmental stress, gets dephosphorylated by calcineurin. Dephosphorylation inhibits its interaction with TORC2, thereby antagonizing TORC2 signaling and mediating calcineurin-dependent actin depolarization. Also functions in heat-induced, calcineurin-mediated uracil permease (FUR4) endocytosis.<ref>PMID:15372071</ref> <ref>PMID:15689497</ref> <ref>PMID:16959779</ref> <ref>PMID:16738335</ref>
 
== References ==
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<references/>
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__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 22574179 is the PubMed ID number.
</StructureSection>
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[[Category: Large Structures]]
{{ABSTRACT_PUBMED_22574179}}
 
==About this Structure==
[[4a6h]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A6H OCA].  
 
==Reference==
<ref group="xtra">PMID:022574179</ref><references group="xtra"/>
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Anand, K.]]
[[Category: Anand K]]
[[Category: Gavin, A C.]]
[[Category: Gavin AC]]
[[Category: Maeda, K.]]
[[Category: Maeda K]]
[[Category: Signaling protein]]
Retrieved from "https://proteopedia.org/4a6h"