4avx: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
 
(6 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:4avx.jpg|left|200px]]


<!--
==Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate (Hgs-Hrs) bound to an IP2 compound at 1.68 A Resolution==
The line below this paragraph, containing "STRUCTURE_4avx", creates the "Structure Box" on the page.
<StructureSection load='4avx' size='340' side='right'caption='[[4avx]], [[Resolution|resolution]] 1.68&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[4avx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AVX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AVX FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.68&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ITP:PHOSPHORIC+ACID+MONO-(2,3,4,6-TETRAHYDROXY-5-PHOSPHONOOXY-CYCLOHEXYL)+ESTER'>ITP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_4avx|  PDB=4avx  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4avx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4avx OCA], [https://pdbe.org/4avx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4avx RCSB], [https://www.ebi.ac.uk/pdbsum/4avx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4avx ProSAT]</span></td></tr>
 
</table>
===Crystal Structure of the Tandem Vhs and Fyve Domains of Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate (Hgs-Hrs) bound to an IP2 compound at 1.68 A Resolution===
== Function ==
 
[https://www.uniprot.org/uniprot/HGS_HUMAN HGS_HUMAN] Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.
 
__TOC__
==About this Structure==
</StructureSection>
[[4avx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AVX OCA].  
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H.]]
[[Category: Large Structures]]
[[Category: Bountra, C.]]
[[Category: Arrowsmith CH]]
[[Category: Bullock, A.]]
[[Category: Bountra C]]
[[Category: Canning, P.]]
[[Category: Bullock A]]
[[Category: Conway, S.]]
[[Category: Canning P]]
[[Category: Delft, F Von.]]
[[Category: Conway S]]
[[Category: Edwards, A M.]]
[[Category: Edwards AM]]
[[Category: Krojer, T.]]
[[Category: Krojer T]]
[[Category: Shrestha, L.]]
[[Category: Shrestha L]]
[[Category: Slowey, A.]]
[[Category: Slowey A]]
[[Category: Vollmar, M.]]
[[Category: Vollmar M]]
[[Category: Weigelt, J.]]
[[Category: Weigelt J]]
[[Category: Williams, E.]]
[[Category: Williams E]]
[[Category: Sgc]]
[[Category: Von Delft F]]
[[Category: Signaling]]
[[Category: Signaling protein]]
[[Category: Structural genomics consortium]]
Retrieved from "https://proteopedia.org/4avx"