4fix: Difference between revisions
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New page: left|200px {{STRUCTURE_4fix| PDB=4fix | SCENE= }} ===Crystal Structure of GlfT2=== ==About this Structure== 4fix is a 2 chain structure with sequence from [... |
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==Crystal Structure of GlfT2== | |||
<StructureSection load='4fix' size='340' side='right'caption='[[4fix]], [[Resolution|resolution]] 2.45Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4fix]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FIX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FIX FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45Å</td></tr> | |||
== | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> | ||
[[4fix]] is a 2 chain structure with sequence from [ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fix OCA], [https://pdbe.org/4fix PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fix RCSB], [https://www.ebi.ac.uk/pdbsum/4fix PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fix ProSAT]</span></td></tr> | ||
[[ | </table> | ||
[[ | == Function == | ||
[[ | [https://www.uniprot.org/uniprot/GLFT2_MYCTU GLFT2_MYCTU] Involved in the polymerization of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacteria cell wall, through successively beta-D-(1->5) and beta-D-(1->6)-galactofuranosyltransferases activities. It transfers the galactofuranosyl (Galf) unit from UDP-galactofuranosyl (UDP-Galf) onto the galactofuranosyl-rhamnosyl-GlcNAc-pyrophosphoryl-undecaprenyl (Galf-Rha-GlcNAc-PP-C55), yielding polygalactofuranosyl-rhamnosyl-GlcNAc-pyrophosphoryl-undecaprenyl ((Galf)x-Rha-GlcNAc-PP-C55). It is able to transfer Galf onto beta-D-(1->5) or beta-D-(1->6) linked acceptor, but has a stronger affinity for beta-D-(1->6) acceptor.<ref>PMID:10934214</ref> <ref>PMID:11304545</ref> <ref>PMID:16704275</ref> <ref>PMID:18055597</ref> <ref>PMID:18423586</ref> <ref>PMID:19571009</ref> | ||
[[ | == References == | ||
[ | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mycobacterium tuberculosis H37Rv]] | ||
[[Category: | [[Category: Lowary TL]] | ||
[[Category: | [[Category: Ng KKS]] | ||
[[Category: Wheatley RW]] | |||
[[Category: Zheng RB]] | |||
