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| <applet load="1eve" size="450" color="white" frame="true" align="right" spinBox="true" script="1eve/E2020_in_ache/6" caption="1eve, resolution 2.50Å" />
| | __NOTOC__ |
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| <big>Welcome to Proteopedia</big>
| | [[Image:Eran_Hodis.jpg|thumb|right|400px|Eran Hodis on the campus of the Weizmann Institute of Science in April of 2008]] |
| ===Proteopedia links 3D structures to clickable text. See for yourself by clicking the green links below!===
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| The X-ray structure of the E2020-''Tc''AChE complex shows that E2020 has a <scene name='1eve/E2020_close_up_with_84_279/6'>unique orientation</scene> along the active-site gorge, extending from the anionic subsite (<scene name='1eve/E2020_close_up_with_84lbld/3'>W84</scene>) of the active site, at the bottom, to the peripheral anionic site (<scene name='1eve/E2020_close_up_with_84_279lbld/2'>near W279</scene>), at the top, via aromatic stacking interactions with conserved aromatic acid residues. E2020 does not, however, interact directly with either the catalytic triad, or the 'oxyanion hole', but only <scene name='1eve/E20_interactionshown/3'>indirectly via solvent molecules</scene>.
| | I am an MD-PhD student at Harvard Medical School and MIT in [http://garrawaylab.dfci.harvard.edu/ Levi Garraway's lab] and [https://www.broadinstitute.org/scientific-community/science/core-faculty-labs/regev-lab/regev-lab-home Aviv Regev's lab]. I research and study the somatic genetics of cancer, particularly melanoma. Previously, I studied computational biology as a graduate student at the Weizmann Institute of Science in [http://genie.weizmann.ac.il/ Eran Segal's lab] focusing on transcriptional regulation in yeast. I'm one of the co-creators of Proteopedia -- this website, a 3D encyclopedia of protein structures -- together with [[User:Joel L. Sussman|Joel L. Sussman]] and [[User:Jaime Prilusky|Jaime Prilusky]] at the Weizmann Institute of Science. |
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| | Contact me at firstname_lastname@hms.harvard.edu |
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| | ==Publications== |
| | <ref group='xtra'>PMID: 25344691</ref><ref group='xtra'>PMID: 25294245</ref><ref group='xtra'>PMID: 25079552</ref><ref group='xtra'>PMID:24625776</ref><ref group='xtra'>PMID:24265154</ref><ref group='xtra'>PMID:24265153</ref><ref group='xtra'>PMID:23770567</ref><ref group='xtra'>PMID:23348506</ref><ref group='xtra'>PMID:23166030</ref><ref group='xtra'>PMID:22987558</ref><ref group='xtra'>PMID:22980975</ref><ref group='xtra'>PMID:22817889</ref><ref group='xtra'>PMID:22622578</ref><ref group='xtra'>PMID: 21567857 </ref><ref group='xtra'>PMID:21536137</ref><ref group='xtra'>PMID:20841429</ref><ref group='xtra'>PMID:19230677</ref><ref group='xtra'>PMID:18854127</ref><ref group='xtra'>PMID:18673581</ref><ref group='xtra'>PMID:17448663</ref> |
| | <references group='xtra'/> |
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| ===What is Proteopedia?===
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| Proteopedia is a free and collaborative, 3D encyclopedia of proteins, RNA, DNA, and their assemblies and interacting small molecules with emphasis on three-dimensional structure where relevant to function.
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| ===What if I am new here?===
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| We invite you to browse Proteopedia and suggest you visit the [[Hemoglobin]], [[1eve | Aricept-Acetylcholinesterase]], and [[1v04 | Serum Paraoxonase-1 by directed evolution]] pages to get a feel for Proteopedia. Remember to click on the green links!
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| We encourage you to check out our site, take a look around, and '''edit pages freely''' (you need a user account to edit at the moment, so ask us for one).
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| '''To request a user account''', email '''eran.hodis''' ''at'' '''weizmann.ac.il'''
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| These resources may help you familiarize yourself with the editing process. Trust us, the editing process is very simple: All text is edited the same way that Wikipedia is edited, so it must be easy! And all scenes are created using our user-friendly ''Scene authoring tools''. Of course it helps to familiarize yourself with the site and how to go about editing, so check out these resources:
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| *A video capture of making a Proteopedia page in 4 minutes at http://www.proteopedia.org/Proteopedia.html
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| *A rough and temporary tutorial available at http://www.proteopedia.org/Proteopedia.html
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| *[[Help:Editing]]
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| *[[Scene authoring tools]]
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| ===Mission Statement===
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| To collect and disseminate structural biological and biological knowledge about proteins, RNA, DNA, and their assemblies and interacting small molecules in a manner that is relevant and accessible to scientists of all the biological and chemical fields.
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| ===Goals for Proteopedia===
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| * To maintain low barriers for contribution.
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| * To continue to develop the concept of tying text to three-dimensional, interactive images.
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| * To serve as a forum for scientists to share, retrieve and discuss information related to proteins, macromolecules, and small molecules and chemicals of interest.
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