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[[Image:3j05.jpg|left|200px]]


{{STRUCTURE_3j05|  PDB=3j05  |  SCENE=  }}
==Three-dimensional structure of Dengue virus serotype 1 complexed with HMAb 14c10 Fab==
 
<SX load='3j05' size='340' side='right' viewer='molstar' caption='[[3j05]], [[Resolution|resolution]] 7.00&Aring;' scene=''>
===Three-dimensional structure of Dengue virus serotype 1 complexed with HMAb 14c10 Fab===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3j05]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_1 Dengue virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J05 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J05 FirstGlance]. <br>
{{ABSTRACT_PUBMED_22723463}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 7&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j05 OCA], [https://pdbe.org/3j05 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j05 RCSB], [https://www.ebi.ac.uk/pdbsum/3j05 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j05 ProSAT]</span></td></tr>
==About this Structure==
</table>
[[3j05]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_1 Dengue virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J05 OCA].  
== Function ==
 
[https://www.uniprot.org/uniprot/Q689G3_9FLAV Q689G3_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS013754_004_099774]
==Reference==
__TOC__
<ref group="xtra">PMID:022723463</ref><references group="xtra"/>
</SX>
[[Category: Dengue virus 1]]
[[Category: Dengue virus 1]]
[[Category: Alonso, S.]]
[[Category: Large Structures]]
[[Category: Chan, S H.]]
[[Category: Alonso S]]
[[Category: Fisher, D.]]
[[Category: Chan SH]]
[[Category: Hanson, B.]]
[[Category: Fisher D]]
[[Category: Kemeny, D M.]]
[[Category: Hanson B]]
[[Category: Kukkaro, P.]]
[[Category: Kemeny DM]]
[[Category: Leo, Y S.]]
[[Category: Kukkaro P]]
[[Category: Lim, A.]]
[[Category: Leo YS]]
[[Category: Lok, S M.]]
[[Category: Lim A]]
[[Category: MacAry, P A.]]
[[Category: Lok SM]]
[[Category: Ng, G.]]
[[Category: MacAry PA]]
[[Category: Ng, M L.]]
[[Category: Ng G]]
[[Category: Ooi, E E.]]
[[Category: Ng ML]]
[[Category: Schul, W.]]
[[Category: Ooi EE]]
[[Category: Shi, P Y.]]
[[Category: Schul W]]
[[Category: Smith, K G.C.]]
[[Category: Shi PY]]
[[Category: Tan, T T.]]
[[Category: Smith KGC]]
[[Category: Teo, E W.]]
[[Category: Tan TT]]
[[Category: Teoh, E P.]]
[[Category: Teo EW]]
[[Category: Yip, A.]]
[[Category: Teoh EP]]
[[Category: Dengue]]
[[Category: Yip A]]
[[Category: E protein]]
[[Category: Envelope protein]]
[[Category: Flavivirus]]
[[Category: Mature virus]]
[[Category: Serotype 1]]
[[Category: Virus]]
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