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[[Image:183d.gif|left|200px]]<br /><applet load="183d" size="350" color="white" frame="true" align="right" spinBox="true"
caption="183d, resolution 1.600&Aring;" />
'''X-RAY STRUCTURE OF A DNA DECAMER CONTAINING 7, 8-DIHYDRO-8-OXOGUANINE'''<br />


==Overview==
==X-RAY STRUCTURE OF A DNA DECAMER CONTAINING 7, 8-DIHYDRO-8-OXOGUANINE==
We have determined the x-ray structure of a DNA fragment containing 7,8-dihydro-8-oxoguanine (G(O)). The structure of the duplex form of d(CCAGOCGCTGG) has been determined to 1.6-A resolution. The results demonstrate that GO forms Watson-Crick base pairs with the opposite C and that G(O) is in the anti conformation. Structural perturbations induced by C.G(O)anti base pairs are subtle. The structure allows us to identify probable elements by which the DNA repair protein MutM recognizes its substrates. Hydrogen bond donors/acceptors within the major groove are the most likely element. In that groove, the pattern of hydrogen-bond donors/acceptors of C.G(O)anti is unique. Additional structural analysis indicates that conversion of G to G(O) would not significantly influence the glycosidic torsion preference of the nucleoside. There is no steric interaction of the 8-oxygen of G(O) with the phospho-deoxyribose backbone.
<StructureSection load='183d' size='340' side='right'caption='[[183d]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[183d]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=183D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=183D FirstGlance]. <br>
183D is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=183D OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8OG:8-OXO-2-DEOXY-GUANOSINE-5-MONOPHOSPHATE'>8OG</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=183d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=183d OCA], [https://pdbe.org/183d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=183d RCSB], [https://www.ebi.ac.uk/pdbsum/183d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=183d ProSAT]</span></td></tr>
X-ray structure of a DNA decamer containing 7,8-dihydro-8-oxoguanine., Lipscomb LA, Peek ME, Morningstar ML, Verghis SM, Miller EM, Rich A, Essigmann JM, Williams LD, Proc Natl Acad Sci U S A. 1995 Jan 31;92(3):719-23. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7846041 7846041]
</table>
[[Category: Protein complex]]
__TOC__
[[Category: Essigmann, J M.]]
</StructureSection>
[[Category: Lipscomb, L A.]]
[[Category: Large Structures]]
[[Category: Miller, E M.]]
[[Category: Essigmann JM]]
[[Category: Morningstar, M L.]]
[[Category: Lipscomb LA]]
[[Category: Peek, M E.]]
[[Category: Miller EM]]
[[Category: Rich, A.]]
[[Category: Morningstar ML]]
[[Category: Verghis, S M.]]
[[Category: Peek ME]]
[[Category: Williams, L D.]]
[[Category: Rich A]]
[[Category: b-dna]]
[[Category: Verghis SM]]
[[Category: double helix]]
[[Category: Williams LD]]
[[Category: modified]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:38:58 2008''

Latest revision as of 06:25, 7 February 2024

X-RAY STRUCTURE OF A DNA DECAMER CONTAINING 7, 8-DIHYDRO-8-OXOGUANINE

183d, resolution 1.60Å

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