2rsv: Difference between revisions
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New page: '''Unreleased structure''' The entry 2rsv is ON HOLD Authors: Koshiba, S., Tochio, N., Yokoyama, J., Kigawa, T. Description: Solution structure of human full-length vaccinia related ki... |
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The entry | ==Solution structure of human full-length vaccinia related kinase 1 (VRK1)== | ||
<StructureSection load='2rsv' size='340' side='right'caption='[[2rsv]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2rsv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RSV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RSV FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rsv OCA], [https://pdbe.org/2rsv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rsv RCSB], [https://www.ebi.ac.uk/pdbsum/2rsv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rsv ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/VRK1_HUMAN VRK1_HUMAN] Pontocerebellar hypoplasia type 1. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/VRK1_HUMAN VRK1_HUMAN] Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity.<ref>PMID:10951572</ref> <ref>PMID:14645249</ref> <ref>PMID:15105425</ref> <ref>PMID:16495336</ref> <ref>PMID:18617507</ref> <ref>PMID:19103756</ref> | |||
==See Also== | |||
*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Kigawa T]] | |||
[[Category: Koshiba S]] | |||
[[Category: Tochio N]] | |||
[[Category: Yokoyama J]] | |||
