4fz5: Difference between revisions
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New page: '''Unreleased structure''' The entry 4fz5 is ON HOLD Authors: Woo, J.R., Kim, S., Shoelson, S.E., Park, S. Description: Crystal Structure of Human TIRAP TIR-domain |
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==Crystal Structure of Human TIRAP TIR-domain== | |||
<StructureSection load='4fz5' size='340' side='right'caption='[[4fz5]], [[Resolution|resolution]] 3.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4fz5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FZ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FZ5 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.6Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fz5 OCA], [https://pdbe.org/4fz5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fz5 RCSB], [https://www.ebi.ac.uk/pdbsum/4fz5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fz5 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TIRAP_HUMAN TIRAP_HUMAN] Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.<ref>PMID:18292575</ref> <ref>PMID:19509286</ref> | |||
==See Also== | |||
*[[TIR domain-containing adapter protein|TIR domain-containing adapter protein]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Kim S]] | |||
[[Category: Park S]] | |||
[[Category: Shoelson SE]] | |||
[[Category: Woo JR]] | |||
