4g0m: Difference between revisions
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New page: '''Unreleased structure''' The entry 4g0m is ON HOLD Authors: Frank, F., Hauver, J., Sonenberg, N., Nagar, B. Description: Crystal structure of Arabidopsis thaliana AGO2 MID domain |
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==Crystal structure of Arabidopsis thaliana AGO2 MID domain== | |||
<StructureSection load='4g0m' size='340' side='right'caption='[[4g0m]], [[Resolution|resolution]] 2.31Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4g0m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G0M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G0M FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.306Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g0m OCA], [https://pdbe.org/4g0m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g0m RCSB], [https://www.ebi.ac.uk/pdbsum/4g0m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g0m ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/AGO2_ARATH AGO2_ARATH] Involved in RNA-mediated post-transcriptional gene silencing (PTGS). Main component of the RNA-induced silencing complex (RISC) that binds to a short guide RNA such as microRNA (miRNA) or small interfering RNA (siRNA). RISC uses the mature miRNA or siRNA as a guide for slicer-directed cleavage of homologous mRNAs to repress gene expression. Associates mainly with siRNAs of 21 nucleotide in length and preferentially recruits small RNAs with a 5' terminal adenosine. Probably involved in antiviral RNA silencing. Associates with siRNA derived from cucumber mosaic virus (CMV). Targeted by turnip yellows virus (TuYV) protein P0 (via F-box-like domain) for probable proteasome degradation and thereby inactivating AGO2 function in RNA silencing. Required to direct NERD-dependent DNA methylation and silencing.<ref>PMID:17869110</ref> <ref>PMID:18342361</ref> <ref>PMID:18342362</ref> <ref>PMID:18344228</ref> <ref>PMID:22940247</ref> | |||
==See Also== | |||
*[[Argonaute 3D structures|Argonaute 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Arabidopsis thaliana]] | |||
[[Category: Large Structures]] | |||
[[Category: Frank F]] | |||
[[Category: Hauver J]] | |||
[[Category: Nagar B]] | |||
[[Category: Sonenberg N]] | |||
