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[[Image:3vha.jpg|left|200px]]


{{STRUCTURE_3vha| PDB=3vha | SCENE= }}
==Hsp90 alpha N-terminal domain in complex with a macrocyclic inhibitor==
<StructureSection load='3vha' size='340' side='right'caption='[[3vha]], [[Resolution|resolution]] 1.39&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3vha]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VHA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VHA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.39&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=VHA:22-METHYL-13,18-DIOXA-7-THIA-3,5-DIAZATETRACYCLO[17.3.1.1~2,6~.1~8,12~]PENTACOSA-1(23),2(25),3,5,8(24),9,11,19,21-NONAEN-4-AMINE'>VHA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vha FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vha OCA], [https://pdbe.org/3vha PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vha RCSB], [https://www.ebi.ac.uk/pdbsum/3vha PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vha ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>


===Hsp90 alpha N-terminal domain in complex with a macrocyclic inhibitor===
==See Also==
 
*[[Heat Shock Protein structures|Heat Shock Protein structures]]
{{ABSTRACT_PUBMED_22192591}}
== References ==
 
<references/>
==About this Structure==
__TOC__
[[3vha]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VHA OCA].
</StructureSection>
 
==Reference==
<ref group="xtra">PMID:022192591</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Fukami, T A.]]
[[Category: Large Structures]]
[[Category: Ono, N.]]
[[Category: Fukami TA]]
[[Category: Chaperone-chaperone inhibitor complex]]
[[Category: Ono N]]
Retrieved from "https://proteopedia.org/3vha"