2q87: Difference between revisions

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[[Image:2q87.png|left|200px]]


{{STRUCTURE_2q87|  PDB=2q87  |  SCENE=  }}
==The Crystal Structure of the Human IRp60 Ectodomain==
 
<StructureSection load='2q87' size='340' side='right'caption='[[2q87]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
===The Crystal Structure of the Human IRp60 Ectodomain===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2q87]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q87 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q87 FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q87 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q87 OCA], [https://pdbe.org/2q87 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q87 RCSB], [https://www.ebi.ac.uk/pdbsum/2q87 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q87 ProSAT]</span></td></tr>
[[2q87]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q87 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/CLM8_HUMAN CLM8_HUMAN] Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation.<ref>PMID:10746781</ref> <ref>PMID:16339535</ref> <ref>PMID:9701027</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q8/2q87_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q87 ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Dimasi, N.]]
[[Category: Large Structures]]
[[Category: Marquez, J A.]]
[[Category: Dimasi N]]
[[Category: All-beta]]
[[Category: Marquez JA]]
[[Category: Cmrf35]]
[[Category: Ig-superfamily]]
[[Category: Ig-v]]
[[Category: Immune system]]
[[Category: Immunoglobulin]]
[[Category: Inhibitory receptor]]
[[Category: Irem]]
[[Category: Irp60]]
[[Category: Membrane protein]]
[[Category: Myelo-monocytic cell]]
[[Category: Natural killer cell ig-like receptor]]
[[Category: Ncr]]
[[Category: Negative regulation of leukocyte]]
[[Category: Negative regulation of natural killer cell]]
[[Category: Negative regulation of natural mast cell]]
[[Category: Nkp44-like]]
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