3u15: Difference between revisions

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[[Image:3u15.png|left|200px]]


{{STRUCTURE_3u15| PDB=3u15 | SCENE= }}
==Structure of hDMX with Dimer Inducing Indolyl Hydantoin RO-2443==
<StructureSection load='3u15' size='340' side='right'caption='[[3u15]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3u15]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U15 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U15 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=03M:(5Z)-5-[(6-CHLORO-7-METHYL-1H-INDOL-3-YL)METHYLIDENE]-3-(3,4-DIFLUOROBENZYL)IMIDAZOLIDINE-2,4-DIONE'>03M</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u15 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u15 OCA], [https://pdbe.org/3u15 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u15 RCSB], [https://www.ebi.ac.uk/pdbsum/3u15 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u15 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MDM4_HUMAN MDM4_HUMAN] Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.<ref>PMID:16163388</ref> <ref>PMID:16511572</ref>


===Structure of hDMX with Dimer Inducing Indolyl Hydantoin RO-2443===
==See Also==
 
*[[MDM4|MDM4]]
{{ABSTRACT_PUBMED_22745160}}
== References ==
 
<references/>
==About this Structure==
__TOC__
[[3u15]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U15 OCA].
</StructureSection>
 
==Reference==
<ref group="xtra">PMID:022745160</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Graves, B J.]]
[[Category: Large Structures]]
[[Category: Janson, C A.]]
[[Category: Graves BJ]]
[[Category: Lukacs, C M.]]
[[Category: Janson CA]]
[[Category: Cell cycle]]
[[Category: Lukacs CM]]
[[Category: Mdm2]]
[[Category: Mdmx]]
[[Category: P53]]
[[Category: Protein binding]]
[[Category: Ubiquitin ligase]]
Retrieved from "https://proteopedia.org/3u15"