1a7h: Difference between revisions

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[[Image:1a7h.gif|left|200px]]<br /><applet load="1a7h" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1a7h, resolution 2.56&Aring;" />
'''GAMMA S CRYSTALLIN C-TERMINAL DOMAIN'''<br />


==Overview==
==GAMMA S CRYSTALLIN C-TERMINAL DOMAIN==
The 2-domain gammaS-crystallin, a highly conserved early evolutionary off-shoot of the gamma-crystallin family, is located in the water-rich region of eye lenses. The expressed C-terminal domain, gammaS-C, has been crystallized and the 2.56 A X-ray structure determined. There are two domains in the asymmetric unit which pair about a distorted twofold axis. One of the domains has an altered conformation in a highly conserved region of the protein, the tyrosine corner. The distorted gammaS-C dimer of domains is compared with the highly symmetrical, equivalent recombinant dimer of C-terminal domains from gammaB-crystallin. Sequence changes close to the interface, that distinguish gammaS from the other gamma-crystallins, are examined in order to evaluate their role in symmetrical domain pairing.
<StructureSection load='1a7h' size='340' side='right'caption='[[1a7h]], [[Resolution|resolution]] 2.56&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1a7h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A7H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A7H FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.56&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a7h OCA], [https://pdbe.org/1a7h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a7h RCSB], [https://www.ebi.ac.uk/pdbsum/1a7h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a7h ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CRYGS_BOVIN CRYGS_BOVIN] Crystallins are the dominant structural components of the vertebrate eye lens.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a7/1a7h_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a7h ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
1A7H is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A7H OCA].
*[[Crystallin 3D structures|Crystallin 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
The C-terminal domains of gammaS-crystallin pair about a distorted twofold axis., Basak AK, Kroone RC, Lubsen NH, Naylor CE, Jaenicke R, Slingsby C, Protein Eng. 1998 May;11(5):337-44. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9681865 9681865]
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Basak, A K.]]
[[Category: Basak AK]]
[[Category: Slingsby, C.]]
[[Category: Slingsby C]]
[[Category: eye lens protein]]
[[Category: eye-lens protein]]
[[Category: gamma crystallin s]]
[[Category: multigene family]]
 
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Retrieved from "https://proteopedia.org/1a7h"