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[[Image:3va2.jpg|left|200px]]


{{STRUCTURE_3va2| PDB=3va2 | SCENE= }}
==Crystal structure of human Interleukin-5 in complex with its alpha receptor==
<StructureSection load='3va2' size='340' side='right'caption='[[3va2]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3va2]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VA2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VA2 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.703&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3va2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3va2 OCA], [https://pdbe.org/3va2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3va2 RCSB], [https://www.ebi.ac.uk/pdbsum/3va2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3va2 ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Interleukin-5 (IL-5), a major hematopoietin, stimulates eosinophil proliferation, migration, and activation, which have been implicated in the pathogenesis of allergic inflammatory diseases, such as asthma. The specific IL-5 receptor (IL-5R) consists of the IL-5 receptor alpha subunit (IL-5RA) and the common receptor beta subunit (betac). IL-5 binding to IL-5R on target cells induces rapid tyrosine phosphorylation and activation of various cellular proteins, including JAK1/JAK2 and STAT1/STAT5. Here, we report the crystal structure of dimeric IL-5 in complex with the IL-5RA extracellular domains. The structure revealed that IL-5RA sandwiches the IL-5 homodimer by three tandem domains, arranged in a "wrench-like" architecture. This association mode was confirmed for human cells expressing IL-5 and the full-length IL-5RA by applying expanded genetic code technology: protein photo-cross-linking experiments revealed that the two proteins interact with each other in vivo in the same manner as that in the crystal structure. Furthermore, a comparison with the previously reported, partial GM-CSF*GM-CSFRA*betac structure enabled us to propose complete structural models for the IL-5 and GM-CSF receptor complexes, and to identify the residues conferring the cytokine-specificities of IL-5RA and GM-CSFRA.


===Crystal structure of human Interleukin-5 in complex with its alpha receptor===
Structural basis of interleukin-5 dimer recognition by its alpha receptor.,Kusano S, Kukimoto-Niino M, Hino N, Ohsawa N, Ikutani M, Takaki S, Sakamoto K, Hara-Yokoyama M, Shirouzu M, Takatsu K, Yokoyama S Protein Sci. 2012 Jun;21(6):850-64. doi: 10.1002/pro.2072. Epub 2012 Apr 23. PMID:22528658<ref>PMID:22528658</ref>


{{ABSTRACT_PUBMED_22528658}}
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3va2" style="background-color:#fffaf0;"></div>


==About this Structure==
==See Also==
[[3va2]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VA2 OCA].
*[[Interleukin 3D structures|Interleukin 3D structures]]
 
*[[Interleukin receptor 3D structures|Interleukin receptor 3D structures]]
==Reference==
== References ==
<ref group="xtra">PMID:022528658</ref><references group="xtra"/>
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Kukimoto-Niino, M.]]
[[Category: Large Structures]]
[[Category: Kusano, S.]]
[[Category: Kukimoto-Niino M]]
[[Category: Shirouzu, M.]]
[[Category: Kusano S]]
[[Category: Yokoyama, S.]]
[[Category: Shirouzu M]]
[[Category: Asthma]]
[[Category: Yokoyama S]]
[[Category: B cell growth]]
[[Category: Cell surface]]
[[Category: Cytokine]]
[[Category: Cytokine-cytokine receptor complex]]
[[Category: Eosinophilic]]
[[Category: Eosinophils proliferation]]
[[Category: Ig secretion]]
[[Category: Jak/stat]]
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