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[[Image:1xbt.png|left|200px]]


{{STRUCTURE_1xbt|  PDB=1xbt  |  SCENE=  }}
==Crystal Structure of Human Thymidine Kinase 1==
 
<StructureSection load='1xbt' size='340' side='right'caption='[[1xbt]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
===Crystal Structure of Human Thymidine Kinase 1===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1xbt]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XBT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XBT FirstGlance]. <br>
{{ABSTRACT_PUBMED_15611477}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TTP:THYMIDINE-5-TRIPHOSPHATE'>TTP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xbt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xbt OCA], [https://pdbe.org/1xbt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xbt RCSB], [https://www.ebi.ac.uk/pdbsum/1xbt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xbt ProSAT]</span></td></tr>
[[1xbt]] is a 8 chain structure of [[Thymidine kinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XBT OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/KITH_HUMAN KITH_HUMAN]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xb/1xbt_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xbt ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Thymidine kinase|Thymidine kinase]]
*[[Thymidine kinase 3D structures|Thymidine kinase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:015611477</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Thymidine kinase]]
[[Category: Large Structures]]
[[Category: Carnrot, C.]]
[[Category: Carnrot C]]
[[Category: Eklund, H.]]
[[Category: Eklund H]]
[[Category: Eriksson, S.]]
[[Category: Eriksson S]]
[[Category: Kosinska, U.]]
[[Category: Kosinska U]]
[[Category: Mikkelsen, N E.]]
[[Category: Mikkelsen NE]]
[[Category: Munch-Petersen, B.]]
[[Category: Munch-Petersen B]]
[[Category: Wang, L.]]
[[Category: Wang L]]
[[Category: Welin, M.]]
[[Category: Welin M]]
[[Category: Zhu, C.]]
[[Category: Zhu C]]
[[Category: Deoxyribonucleoside kinase]]
[[Category: Feedback inhibitor]]
[[Category: Transferase]]
[[Category: Zinc-binding domain]]
Retrieved from "https://proteopedia.org/1xbt"