1k01: Difference between revisions

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[[Image:1k01.png|left|200px]]


{{STRUCTURE_1k01|  PDB=1k01  |  SCENE=  }}
==Structural Basis for the Interaction of Antibiotics with the Peptidyl Transferase Center in Eubacteria==
 
<StructureSection load='1k01' size='340' side='right'caption='[[1k01]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
===Structural Basis for the Interaction of Antibiotics with the Peptidyl Transferase Center in Eubacteria===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1k01]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K01 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K01 FirstGlance]. <br>
{{ABSTRACT_PUBMED_11677599}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLM:CHLORAMPHENICOL'>CLM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k01 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k01 OCA], [https://pdbe.org/1k01 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k01 RCSB], [https://www.ebi.ac.uk/pdbsum/1k01 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k01 ProSAT]</span></td></tr>
[[1k01]] is a 4 chain structure of [[Ribosomal protein L22]], [[Ribosomal protein L32]], [[Ribosomal protein L4]] and [[Ribosome]] with sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K01 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/RL4_DEIRA RL4_DEIRA] One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly (By similarity).[HAMAP-Rule:MF_01328_B]  Makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit.[HAMAP-Rule:MF_01328_B]  This protein is located close to the polypeptide exit tunnel, and interacts with the modified macrolide azithromycin, which blocks the tunnel.[HAMAP-Rule:MF_01328_B]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k0/1k01_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k01 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
Line 14: Line 25:
*[[Ribosomal protein L32|Ribosomal protein L32]]
*[[Ribosomal protein L32|Ribosomal protein L32]]
*[[Ribosomal protein L4|Ribosomal protein L4]]
*[[Ribosomal protein L4|Ribosomal protein L4]]
*[[Ribosome|Ribosome]]
__TOC__
 
</StructureSection>
==Reference==
<ref group="xtra">PMID:011677599</ref><references group="xtra"/>
[[Category: Deinococcus radiodurans]]
[[Category: Deinococcus radiodurans]]
[[Category: Albrecht, R.]]
[[Category: Large Structures]]
[[Category: Bashan, A.]]
[[Category: Albrecht R]]
[[Category: Franceschi, F.]]
[[Category: Bashan A]]
[[Category: Harms, J.]]
[[Category: Franceschi F]]
[[Category: Schluenzen, F.]]
[[Category: Harms J]]
[[Category: Tocilj, A.]]
[[Category: Schluenzen F]]
[[Category: Yonath, A.]]
[[Category: Tocilj A]]
[[Category: Zarivach, R.]]
[[Category: Yonath A]]
[[Category: 23]]
[[Category: Zarivach R]]
[[Category: 50]]
[[Category: 5]]
[[Category: Antibiotic]]
[[Category: Chloramphenicol]]
[[Category: Peptidyl transferase center]]
[[Category: Ribosome]]
Retrieved from "https://proteopedia.org/1k01"