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[[Image:1amn.jpg|left|200px]]<br /><applet load="1amn" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1amn, resolution 2.8&Aring;" />
'''TRANSITION STATE ANALOG: ACETYLCHOLINESTERASE COMPLEXED WITH M-(N,N,N-TRIMETHYLAMMONIO)TRIFLUOROACETOPHENONE'''<br />


==About this Structure==
==TRANSITION STATE ANALOG: ACETYLCHOLINESTERASE COMPLEXED WITH M-(N,N,N-TRIMETHYLAMMONIO)TRIFLUOROACETOPHENONE==
1AMN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=NAF:'>NAF</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AMN OCA].
<StructureSection load='1amn' size='340' side='right'caption='[[1amn]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
[[Category: Acetylcholinesterase]]
== Structural highlights ==
[[Category: Single protein]]
<table><tr><td colspan='2'>[[1amn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Tetronarce_californica Tetronarce californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AMN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AMN FirstGlance]. <br>
[[Category: Torpedo californica]]
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
[[Category: Harel, M.]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAF:M-(N,N,N-TRIMETHYLAMMONIO)-2,2,2-TRIFLUORO-1,1-DIHYDROXYETHYLBENZENE'>NAF</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
[[Category: Silman, I.]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1amn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1amn OCA], [https://pdbe.org/1amn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1amn RCSB], [https://www.ebi.ac.uk/pdbsum/1amn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1amn ProSAT]</span></td></tr>
[[Category: Sussman, J L.]]
</table>
[[Category: NAF]]
== Function ==
[[Category: SO4]]
[https://www.uniprot.org/uniprot/ACES_TETCF ACES_TETCF] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. May be involved in cell-cell interactions.
[[Category: alternative splicing]]
== Evolutionary Conservation ==
[[Category: glycoprotein]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: gpi-anchor]]
Check<jmol>
[[Category: hydrolase]]
  <jmolCheckbox>
[[Category: membrane]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/am/1amn_consurf.spt"</scriptWhenChecked>
[[Category: muscle]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: nerve]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: neurotransmitter degradation]]
  </jmolCheckbox>
[[Category: serine esterase]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1amn ConSurf].
[[Category: signal]]
<div style="clear:both"></div>
[[Category: synapse]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:46:08 2008''
==See Also==
*[[Acetylcholinesterase 3D structures|Acetylcholinesterase 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Tetronarce californica]]
[[Category: Harel M]]
[[Category: Silman I]]
[[Category: Sussman JL]]
Retrieved from "https://proteopedia.org/1amn"