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[[Image:1ze2.png|left|200px]]


{{STRUCTURE_1ze2|  PDB=1ze2  |  SCENE=  }}
==Conformational change of pseudouridine 55 synthase upon its association with RNA substrate==
 
<StructureSection load='1ze2' size='340' side='right'caption='[[1ze2]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
===Conformational change of pseudouridine 55 synthase upon its association with RNA substrate===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1ze2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZE2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZE2 FirstGlance]. <br>
{{ABSTRACT_PUBMED_14990747}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FHU:(5S,6R)-5-FLUORO-6-HYDROXY-PSEUDOURIDINE-5-MONOPHOSPHATE'>FHU</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ze2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ze2 OCA], [https://pdbe.org/1ze2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ze2 RCSB], [https://www.ebi.ac.uk/pdbsum/1ze2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ze2 ProSAT]</span></td></tr>
[[1ze2]] is a 4 chain structure of [[TRNA pseudouridine synthase]] with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZE2 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/TRUB_THEMA TRUB_THEMA] Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ze/1ze2_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ze2 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[TRNA pseudouridine synthase|TRNA pseudouridine synthase]]
*[[Guide-independent Pseudouridine synthase|Guide-independent Pseudouridine synthase]]
 
*[[Pseudouridine synthase|Pseudouridine synthase]]
==Reference==
*[[Pseudouridine synthase 3D structures|Pseudouridine synthase 3D structures]]
<ref group="xtra">PMID:014990747</ref><references group="xtra"/>
__TOC__
[[Category: Pseudouridylate synthase]]
</StructureSection>
[[Category: Large Structures]]
[[Category: Thermotoga maritima]]
[[Category: Thermotoga maritima]]
[[Category: Huang, R H.]]
[[Category: Huang RH]]
[[Category: Phannachet, K.]]
[[Category: Phannachet K]]
[[Category: Lyase-rna complex]]
[[Category: Protein-rna complex]]
Retrieved from "https://proteopedia.org/1ze2"