1au6: Difference between revisions
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== | ==SOLUTION STRUCTURE OF DNA D(CATGCATG) INTERSTRAND-CROSSLINKED BY BISPLATIN COMPOUND (1,1/T,T), NMR, MINIMIZED AVERAGE STRUCTURE== | ||
<StructureSection load='1au6' size='340' side='right'caption='[[1au6]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1au6]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AU6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AU6 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, models</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BPT:BIS(TRANS-PLATINUM+ETHYLENEDIAMINE+DIAMINE+CHLORO)COMPLEX'>BPT</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1au6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1au6 OCA], [https://pdbe.org/1au6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1au6 RCSB], [https://www.ebi.ac.uk/pdbsum/1au6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1au6 ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The bifunctional platinum compound, [(trans-PtCI(NH)3)2)2(H2N(CH2)4NH2)]2+, forms a stable adduct with the self-complementary DNA oligomer CATGCATG, with the two platinum atoms coordinated at the N7 positions of the two symmetrical G4 nucleotides. The NMR-derived structure shows that the DNA octamer forms a novel hairpin structure with the platinated G4 residue adopting a syn conformation and the guanine base in the minor groove. Two such hairpins stack end-over-end and are linked together by the butanediamine tether to form a dumbbell structure. Such unusual structural distortion is different from that of the anticancer drug cisplatin-DNA adduct and may provide clues to explain the distinct biological activities of the two compounds. | The bifunctional platinum compound, [(trans-PtCI(NH)3)2)2(H2N(CH2)4NH2)]2+, forms a stable adduct with the self-complementary DNA oligomer CATGCATG, with the two platinum atoms coordinated at the N7 positions of the two symmetrical G4 nucleotides. The NMR-derived structure shows that the DNA octamer forms a novel hairpin structure with the platinated G4 residue adopting a syn conformation and the guanine base in the minor groove. Two such hairpins stack end-over-end and are linked together by the butanediamine tether to form a dumbbell structure. Such unusual structural distortion is different from that of the anticancer drug cisplatin-DNA adduct and may provide clues to explain the distinct biological activities of the two compounds. | ||
A novel DNA structure induced by the anticancer bisplatinum compound crosslinked to a GpC site in DNA.,Yang D, van Boom SS, Reedijk J, van Boom JH, Farrell N, Wang AH Nat Struct Biol. 1995 Jul;2(7):577-8. PMID:7664126<ref>PMID:7664126</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 1au6" style="background-color:#fffaf0;"></div> | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: Farrell | __TOC__ | ||
[[Category: Reedijk | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Farrell N]] | ||
[[Category: | [[Category: Reedijk J]] | ||
[[Category: | [[Category: Van Boom JH]] | ||
[[Category: Van Boom SSGE]] | |||
[[Category: Wang AH-J]] | |||
[[Category: Yang D]] | |||
Latest revision as of 05:24, 13 August 2026
SOLUTION STRUCTURE OF DNA D(CATGCATG) INTERSTRAND-CROSSLINKED BY BISPLATIN COMPOUND (1,1/T,T), NMR, MINIMIZED AVERAGE STRUCTURE
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