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[[Image:3cwt.png|left|200px]]


{{STRUCTURE_3cwt|  PDB=3cwt  |  SCENE=  }}
==Crystal Structure of an AlkA Host/Guest Complex 2'-fluoro-2'-deoxyinosine:Adenine Base Pair==
 
<StructureSection load='3cwt' size='340' side='right'caption='[[3cwt]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
===Crystal Structure of an AlkA Host/Guest Complex 2'-fluoro-2'-deoxyinosine:Adenine Base Pair===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3cwt]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CWT FirstGlance]. <br>
{{ABSTRACT_PUBMED_18682218}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2FI:2-FLUORO-2-DEOXYINOSINE'>2FI</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cwt OCA], [https://pdbe.org/3cwt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cwt RCSB], [https://www.ebi.ac.uk/pdbsum/3cwt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cwt ProSAT]</span></td></tr>
[[3cwt]] is a 8 chain structure of [[DNA glycosylate]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWT OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/3MG2_ECOLI 3MG2_ECOLI] Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, 3-methylguanine, 7-methylguanine, O2-methylthymine, and O2-methylcytosine from the damaged DNA polymer formed by alkylation lesions.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cw/3cwt_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cwt ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[DNA glycosylate|DNA glycosylate]]
*[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:018682218</ref><references group="xtra"/>
[[Category: DNA-3-methyladenine glycosylase II]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Bowman, B R.]]
[[Category: Large Structures]]
[[Category: Lee, S.]]
[[Category: Bowman BR]]
[[Category: Verdine, G L.]]
[[Category: Lee S]]
[[Category: Wang, S.]]
[[Category: Verdine GL]]
[[Category: 2'-fluoro-2'-deoxyinosine]]
[[Category: Wang S]]
[[Category: Alka]]
[[Category: Dna damage]]
[[Category: Dna repair]]
[[Category: Dna structure]]
[[Category: Host-guest complex]]
[[Category: Hydrolase]]
[[Category: Hydrolase-dna complex]]
Retrieved from "https://proteopedia.org/3cwt"