3shz: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,438 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,438 edits
No edit summary
 
(6 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:3shz.png|left|200px]]


{{STRUCTURE_3shz|  PDB=3shz  |  SCENE=  }}
==Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors==
 
<StructureSection load='3shz' size='340' side='right'caption='[[3shz]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
===Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3shz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SHZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SHZ FirstGlance]. <br>
{{ABSTRACT_PUBMED_21714539}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.449&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CO:5-CHLORO-6-ETHYL-2-{5-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]-2-PROPOXYPHENYL}PYRIMIDIN-4(3H)-ONE'>5CO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3shz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3shz OCA], [https://pdbe.org/3shz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3shz RCSB], [https://www.ebi.ac.uk/pdbsum/3shz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3shz ProSAT]</span></td></tr>
[[3shz]] is a 1 chain structure of [[Phosphodiesterase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SHZ OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.


==See Also==
==See Also==
*[[Phosphodiesterase|Phosphodiesterase]]
*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:021714539</ref><references group="xtra"/>
[[Category: 3',5'-cyclic-GMP phosphodiesterase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Chen, T.]]
[[Category: Large Structures]]
[[Category: Chen, T T.]]
[[Category: Chen T]]
[[Category: Xu, Y C.]]
[[Category: Chen TT]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Xu YC]]
[[Category: Pde5a inhibitor]]
Retrieved from "https://proteopedia.org/3shz"