3t8w: Difference between revisions

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[[Image:3t8w.png|left|200px]]


{{STRUCTURE_3t8w|  PDB=3t8w  |  SCENE=  }}
==A bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases==
 
<StructureSection load='3t8w' size='340' side='right'caption='[[3t8w]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
===A bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3t8w]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T8W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T8W FirstGlance]. <br>
{{ABSTRACT_PUBMED_21844374}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=2PE:NONAETHYLENE+GLYCOL'>2PE</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=DGZ:N-((2R,3S,6S,18S,21S)-2-AMINO-18-(4-BENZOYLBENZYL)-21-CARBAMOYL-3-HYDROXY-6-(NAPHTHALEN-2-YLMETHYL)-4,7,16,19-TETRAOXO-1-PHENYL-11,14-DIOXA-5,8,17,20-TETRAAZAPENTACOSAN-25-YL)HEX-5-YNAMIDE'>DGZ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t8w OCA], [https://pdbe.org/3t8w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t8w RCSB], [https://www.ebi.ac.uk/pdbsum/3t8w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t8w ProSAT]</span></td></tr>
[[3t8w]] is a 12 chain structure of [[Aminopeptidase]] with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T8W OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q8IL11_PLAF7 Q8IL11_PLAF7]


==See Also==
==See Also==
*[[Aminopeptidase|Aminopeptidase]]
*[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:021844374</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: Plasmodium falciparum]]
[[Category: Plasmodium falciparum 3D7]]
[[Category: Greebaum, D C.]]
[[Category: Greebaum DC]]
[[Category: Klemba, M.]]
[[Category: Klemba M]]
[[Category: McGowan, S.]]
[[Category: McGowan S]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: M17-leucyl aminopeptidase]]
[[Category: Metallo-aminopeptidase]]
[[Category: Protease]]

Latest revision as of 08:37, 20 March 2024

A bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases

3t8w, resolution 2.00Å

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