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[[Image:2azr.png|left|200px]]


{{STRUCTURE_2azr|  PDB=2azr  |  SCENE=  }}
==Crystal structure of PTP1B with Bicyclic Thiophene inhibitor==
 
<StructureSection load='2azr' size='340' side='right'caption='[[2azr]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
===Crystal structure of PTP1B with Bicyclic Thiophene inhibitor===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2azr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AZR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AZR FirstGlance]. <br>
{{ABSTRACT_PUBMED_16303309}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=982:3-(CARBOXYMETHOXY)THIENO[2,3-B]PYRIDINE-2-CARBOXYLIC+ACID'>982</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2azr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2azr OCA], [https://pdbe.org/2azr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2azr RCSB], [https://www.ebi.ac.uk/pdbsum/2azr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2azr ProSAT]</span></td></tr>
[[2azr]] is a 1 chain structure of [[Proten tyrosine phosphatase]] and [[Tyrosine phosphatase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AZR OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/az/2azr_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2azr ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Proten tyrosine phosphatase|Proten tyrosine phosphatase]]
*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
*[[Tyrosine phosphatase|Tyrosine phosphatase]]
== References ==
 
<references/>
==Reference==
__TOC__
<ref group="xtra">PMID:016303309</ref><references group="xtra"/>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein-tyrosine-phosphatase]]
[[Category: Large Structures]]
[[Category: Binnun, E.]]
[[Category: Binnun E]]
[[Category: Erbe, D V.]]
[[Category: Erbe DV]]
[[Category: Follows, B C.]]
[[Category: Follows BC]]
[[Category: Foreman, K.]]
[[Category: Foreman K]]
[[Category: Joseph-McCarthy, D.]]
[[Category: Joseph-McCarthy D]]
[[Category: Kirincich, S J.]]
[[Category: Kirincich SJ]]
[[Category: Lee, J.]]
[[Category: Lee J]]
[[Category: Moretto, A F.]]
[[Category: Moretto AF]]
[[Category: Smith, M J.]]
[[Category: Smith MJ]]
[[Category: Tam, S K.]]
[[Category: Tam SK]]
[[Category: Tam, S Y.]]
[[Category: Tam SY]]
[[Category: Wan, Z K.]]
[[Category: Wan ZK]]
[[Category: Wilson, D P.]]
[[Category: Wilson DP]]
[[Category: Xu, W X.]]
[[Category: Xu WX]]
[[Category: Zhang, Y L.]]
[[Category: Zhang YL]]
[[Category: Bicyclic thiophene]]
[[Category: Hydrolase]]
[[Category: Hydrolyase]]
[[Category: Protein tyrosine phosphatase]]
Retrieved from "https://proteopedia.org/2azr"