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[[Image:1jye.png|left|200px]]


{{STRUCTURE_1jye|  PDB=1jye  |  SCENE=  }}
==Structure of a Dimeric Lac Repressor with C-terminal Deletion and K84L Substitution==
 
<StructureSection load='1jye' size='340' side='right'caption='[[1jye]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
===Structure of a Dimeric Lac Repressor with C-terminal Deletion and K84L Substitution===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1jye]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JYE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JYE FirstGlance]. <br>
{{ABSTRACT_PUBMED_11601849}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jye OCA], [https://pdbe.org/1jye PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jye RCSB], [https://www.ebi.ac.uk/pdbsum/1jye PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jye ProSAT]</span></td></tr>
[[1jye]] is a 1 chain structure of [[Lac repressor]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JYE OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/LACI_ECOLI LACI_ECOLI] Repressor of the lactose operon. Binds allolactose as an inducer.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jy/1jye_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jye ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Lac repressor|Lac repressor]]
*[[Lac repressor|Lac repressor]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:011601849</ref><references group="xtra"/>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Barry, J.]]
[[Category: Large Structures]]
[[Category: Bell, C E.]]
[[Category: Barry J]]
[[Category: Lewis, M.]]
[[Category: Bell CE]]
[[Category: Matthews, K S.]]
[[Category: Lewis M]]
[[Category: Gene regulation]]
[[Category: Matthews KS]]
[[Category: Protein dna-binding]]
[[Category: Protein stability]]
[[Category: Transcription]]

Latest revision as of 07:42, 7 February 2024

Structure of a Dimeric Lac Repressor with C-terminal Deletion and K84L Substitution

1jye, resolution 1.70Å

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