2i9k: Difference between revisions

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[[Image:2i9k.png|left|200px]]


{{STRUCTURE_2i9k|  PDB=2i9k  |  SCENE=  }}
==Engineered Extrahelical Base Destabilization Enhances Sequence Discrimination of DNA Methyltransferase M.HhaI==
 
<StructureSection load='2i9k' size='340' side='right'caption='[[2i9k]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
===Engineered Extrahelical Base Destabilization Enhances Sequence Discrimination of DNA Methyltransferase M.HhaI===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2i9k]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_haemolyticus Haemophilus haemolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I9K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I9K FirstGlance]. <br>
{{ABSTRACT_PUBMED_16919299}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i9k OCA], [https://pdbe.org/2i9k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i9k RCSB], [https://www.ebi.ac.uk/pdbsum/2i9k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i9k ProSAT]</span></td></tr>
[[2i9k]] is a 3 chain structure of [[DNA methyltransferase]] with sequence from [http://en.wikipedia.org/wiki/Haemophilus_haemolyticus Haemophilus haemolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I9K OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/MTH1_HAEPH MTH1_HAEPH] This methylase recognizes the double-stranded sequence GCGC, causes specific methylation on C-2 on both strands, and protects the DNA from cleavage by the HhaI endonuclease.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i9/2i9k_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i9k ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[DNA methyltransferase|DNA methyltransferase]]
*[[DNA methyltransferase 3D structures|DNA methyltransferase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:016919299</ref><references group="xtra"/>
[[Category: Deleted entry]]
[[Category: Haemophilus haemolyticus]]
[[Category: Haemophilus haemolyticus]]
[[Category: Perona, J J.]]
[[Category: Large Structures]]
[[Category: Reich, N O.]]
[[Category: De Los Rios S]]
[[Category: Rios, S De Los.]]
[[Category: Perona JJ]]
[[Category: Shieh, F K.]]
[[Category: Reich NO]]
[[Category: Youngblood, B.]]
[[Category: Shieh FK]]
[[Category: Phe124ala mutation in m hhai]]
[[Category: Youngblood B]]
[[Category: Transferase-dna complex]]
Retrieved from "https://proteopedia.org/2i9k"