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[[Image:1lat.png|left|200px]]


{{STRUCTURE_1lat|  PDB=1lat  |  SCENE=  }}
==GLUCOCORTICOID RECEPTOR MUTANT/DNA COMPLEX==
 
<StructureSection load='1lat' size='340' side='right'caption='[[1lat]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
===GLUCOCORTICOID RECEPTOR MUTANT/DNA COMPLEX===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1lat]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LAT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LAT FirstGlance]. <br>
{{ABSTRACT_PUBMED_7664096}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lat OCA], [https://pdbe.org/1lat PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lat RCSB], [https://www.ebi.ac.uk/pdbsum/1lat PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lat ProSAT]</span></td></tr>
[[1lat]] is a 4 chain structure of [[Glucocorticoid receptor]] with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LAT OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/GCR_RAT GCR_RAT] Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation (By similarity).<ref>PMID:12917342</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/la/1lat_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lat ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Glucocorticoid receptor|Glucocorticoid receptor]]
*[[Glucocorticoid receptor 3D structures|Glucocorticoid receptor 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:007664096</ref><ref group="xtra">PMID:011258480</ref><ref group="xtra">PMID:014702633</ref><ref group="xtra">PMID:015048824</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Gewirth, D T.]]
[[Category: Gewirth DT]]
[[Category: Sigler, P B.]]
[[Category: Sigler PB]]
[[Category: Dna binding regulatory protein]]
[[Category: Glucocorticoid receptor]]
[[Category: Transcription-dna complex]]
Retrieved from "https://proteopedia.org/1lat"