3rto: Difference between revisions

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[[Image:3rto.png|left|200px]]


{{STRUCTURE_3rto| PDB=3rto | SCENE= }}
==Acoustically mounted porcine insulin microcrystals yield an X-ray SAD structure==
<StructureSection load='3rto' size='340' side='right'caption='[[3rto]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3rto]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RTO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RTO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rto OCA], [https://pdbe.org/3rto PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rto RCSB], [https://www.ebi.ac.uk/pdbsum/3rto PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rto ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/INS_PIG INS_PIG] Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
We demonstrate a general strategy for determining structures from showers of microcrystals. It uses acoustic droplet ejection to transfer 2.5 nL droplets from the surface of microcrystal slurries, through the air, onto mounting micromesh pins. Individual microcrystals are located by raster-scanning a several-micrometer X-ray beam across the cryocooled micromeshes. X-ray diffraction data sets merged from several micrometer-sized crystals are used to determine 1.8 A resolution crystal structures.


===Acoustically mounted porcine insulin microcrystals yield an X-ray SAD structure===
Acoustically Mounted Microcrystals Yield High-Resolution X-ray Structures.,Soares AS, Engel MA, Stearns R, Datwani S, Olechno J, Ellson R, Skinner JM, Allaire M, Orville AM Biochemistry. 2011 May 9. PMID:21542590<ref>PMID:21542590</ref>


{{ABSTRACT_PUBMED_21542590}}
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
==About this Structure==
<div class="pdbe-citations 3rto" style="background-color:#fffaf0;"></div>
[[3rto]] is a 4 chain structure of [[Molecular Playground/Insulin]] with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RTO OCA].


==See Also==
==See Also==
*[[Molecular Playground/Insulin|Molecular Playground/Insulin]]
*[[Insulin 3D Structures|Insulin 3D Structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:021542590</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
[[Category: Allaire, M.]]
[[Category: Allaire M]]
[[Category: Datwani, S.]]
[[Category: Datwani S]]
[[Category: Ellson, R.]]
[[Category: Ellson R]]
[[Category: Engel, M A.]]
[[Category: Engel MA]]
[[Category: Olechno, J.]]
[[Category: Olechno J]]
[[Category: Orville, A M.]]
[[Category: Orville AM]]
[[Category: Skinner, J M.]]
[[Category: Skinner JM]]
[[Category: Soares, A S.]]
[[Category: Soares AS]]
[[Category: Stearns, R.]]
[[Category: Stearns R]]
[[Category: Hormone]]
Retrieved from "https://proteopedia.org/3rto"