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[[Image:2ipp.png|left|200px]]


{{STRUCTURE_2ipp|  PDB=2ipp  |  SCENE=  }}
==Crystal Structure of the tetragonal form of human liver cathepsin B==
 
<StructureSection load='2ipp' size='340' side='right'caption='[[2ipp]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
===Crystal Structure of the tetragonal form of human liver cathepsin B===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2ipp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IPP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IPP FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PYS:2-PYRIDINETHIOL'>PYS</scene></td></tr>
[[2ipp]] is a 2 chain structure of [[Cathepsin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IPP OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ipp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ipp OCA], [https://pdbe.org/2ipp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ipp RCSB], [https://www.ebi.ac.uk/pdbsum/2ipp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ipp ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CATB_HUMAN CATB_HUMAN] Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ip/2ipp_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ipp ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Cathepsin|Cathepsin]]
*[[Cathepsin 3D structures|Cathepsin 3D structures]]
[[Category: Cathepsin B]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Campbell, R L.]]
[[Category: Large Structures]]
[[Category: Hasnain, S.]]
[[Category: Campbell RL]]
[[Category: Hirama, T.]]
[[Category: Hasnain S]]
[[Category: Huber, C P.]]
[[Category: Hirama T]]
[[Category: To, R.]]
[[Category: Huber CP]]
[[Category: Cathepsin]]
[[Category: To R]]
[[Category: Cysteine proteinase]]
[[Category: Hydrolase]]
Retrieved from "https://proteopedia.org/2ipp"