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[[Image:1n8f.png|left|200px]]


{{STRUCTURE_1n8f|  PDB=1n8f  |  SCENE=  }}
==Crystal structure of E24Q mutant of phenylalanine-regulated 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (DAHP synthase) from Escherichia Coli in complex with Mn2+ and PEP==
 
<StructureSection load='1n8f' size='340' side='right'caption='[[1n8f]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
===Crystal structure of E24Q mutant of phenylalanine-regulated 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (DAHP synthase) from Escherichia Coli in complex with Mn2+ and PEP===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1n8f]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N8F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N8F FirstGlance]. <br>
{{ABSTRACT_PUBMED_12667068}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PEP:PHOSPHOENOLPYRUVATE'>PEP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n8f OCA], [https://pdbe.org/1n8f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n8f RCSB], [https://www.ebi.ac.uk/pdbsum/1n8f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n8f ProSAT]</span></td></tr>
[[1n8f]] is a 4 chain structure of [[Aldolase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N8F OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/AROG_ECOLI AROG_ECOLI] Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n8/1n8f_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n8f ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Aldolase|Aldolase]]
*[[DAHP synthase 3D structures|DAHP synthase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:012667068</ref><references group="xtra"/>
[[Category: 3-deoxy-7-phosphoheptulonate synthase]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Bauerle, R.]]
[[Category: Large Structures]]
[[Category: Kretsinger, R H.]]
[[Category: Bauerle R]]
[[Category: Shumilin, I A.]]
[[Category: Kretsinger RH]]
[[Category: Metal binding protein]]
[[Category: Shumilin IA]]
Retrieved from "https://proteopedia.org/1n8f"