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[[Image:1fjx.png|left|200px]]


{{STRUCTURE_1fjx|  PDB=1fjx  |  SCENE=  }}
==STRUCTURE OF TERNARY COMPLEX OF HHAI METHYLTRANSFERASE MUTANT (T250G) IN COMPLEX WITH DNA AND ADOHCY==
 
<StructureSection load='1fjx' size='340' side='right'caption='[[1fjx]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
===STRUCTURE OF TERNARY COMPLEX OF HHAI METHYLTRANSFERASE MUTANT (T250G) IN COMPLEX WITH DNA AND ADOHCY===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1fjx]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_haemolyticus Haemophilus haemolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FJX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FJX FirstGlance]. <br>
{{ABSTRACT_PUBMED_11102456}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.26&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fjx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fjx OCA], [https://pdbe.org/1fjx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fjx RCSB], [https://www.ebi.ac.uk/pdbsum/1fjx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fjx ProSAT]</span></td></tr>
[[1fjx]] is a 3 chain structure of [[DNA methyltransferase]] with sequence from [http://en.wikipedia.org/wiki/Haemophilus_haemolyticus Haemophilus haemolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FJX OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/MTH1_HAEPH MTH1_HAEPH] This methylase recognizes the double-stranded sequence GCGC, causes specific methylation on C-2 on both strands, and protects the DNA from cleavage by the HhaI endonuclease.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fj/1fjx_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fjx ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[DNA methyltransferase|DNA methyltransferase]]
*[[DNA methyltransferase 3D structures|DNA methyltransferase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:011102456</ref><references group="xtra"/>
[[Category: Deleted entry]]
[[Category: Haemophilus haemolyticus]]
[[Category: Haemophilus haemolyticus]]
[[Category: Cheng, X.]]
[[Category: Large Structures]]
[[Category: Dong, A.]]
[[Category: Cheng X]]
[[Category: Klimasauskas, S.]]
[[Category: Dong A]]
[[Category: Vilkaitis, G.]]
[[Category: Klimasauskas S]]
[[Category: Weinhold, E.]]
[[Category: Vilkaitis G]]
[[Category: Adomet-dependent methyltransferase fold protein-dna-cofactor complex]]
[[Category: Weinhold E]]
[[Category: Transferase-dna complex]]
Retrieved from "https://proteopedia.org/1fjx"