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[[Image:1s14.png|left|200px]]


{{STRUCTURE_1s14|  PDB=1s14  |  SCENE=  }}
==Crystal structure of Escherichia coli Topoisomerase IV ParE 24kDa subunit==
 
<StructureSection load='1s14' size='340' side='right'caption='[[1s14]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
===Crystal structure of Escherichia coli Topoisomerase IV ParE 24kDa subunit===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1s14]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S14 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S14 FirstGlance]. <br>
{{ABSTRACT_PUBMED_15105144}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NOV:NOVOBIOCIN'>NOV</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s14 OCA], [https://pdbe.org/1s14 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s14 RCSB], [https://www.ebi.ac.uk/pdbsum/1s14 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s14 ProSAT]</span></td></tr>
[[1s14]] is a 2 chain structure of [[Topoisomerase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S14 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/PARE_ECOLI PARE_ECOLI] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. MukB stimulates the relaxation activity of topoisomerase IV and also has a modest effect on decatenation.<ref>PMID:21300644</ref> <ref>PMID:15105144</ref> <ref>PMID:20921377</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s1/1s14_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s14 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Topoisomerase|Topoisomerase]]
*[[Topoisomerase 3D structures|Topoisomerase 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:015105144</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Gross, C H.]]
[[Category: Large Structures]]
[[Category: Wei, Y.]]
[[Category: Gross CH]]
[[Category: Alpha/beta globular protein]]
[[Category: Wei Y]]
[[Category: Isomerase]]
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