2kki: Difference between revisions
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==Solution structure of human Interleukin 1a== | |||
<StructureSection load='2kki' size='340' side='right'caption='[[2kki]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2kki]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KKI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KKI FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kki FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kki OCA], [https://pdbe.org/2kki PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kki RCSB], [https://www.ebi.ac.uk/pdbsum/2kki PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kki ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/IL1A_HUMAN IL1A_HUMAN] Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kk/2kki_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kki ConSurf]. | |||
<div style="clear:both"></div> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
As part of our NMR structure determination of the human Interleukin-1alpha, we report nearly complete NMR chemical shift assignments for the (1)H, (13)C and (15)N nuclei. | |||
1H, 13C and 15N backbone and side chain resonance assignments of human interleukin 1alpha.,Chang HK, Mohan SK, Chin Y Biomol NMR Assign. 2010 Apr;4(1):59-60. Epub 2010 Jan 28. PMID:20108067<ref>PMID:20108067</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 2kki" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
*[[Interleukin|Interleukin]] | *[[Interleukin 3D structures|Interleukin 3D structures]] | ||
== References == | |||
== | <references/> | ||
< | __TOC__ | ||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Chang H-K]] | ||
[[Category: | [[Category: Mohan SK]] | ||
[[Category: | [[Category: Yu C]] | ||
Latest revision as of 19:12, 29 May 2024
Solution structure of human Interleukin 1a
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