1bn0: Difference between revisions

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[[Image:1bn0.gif|left|200px]]<br /><applet load="1bn0" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1bn0" />
'''SL3 HAIRPIN FROM THE PACKAGING SIGNAL OF HIV-1, NMR, 11 STRUCTURES'''<br />


==Overview==
==SL3 HAIRPIN FROM THE PACKAGING SIGNAL OF HIV-1, NMR, 11 STRUCTURES==
<StructureSection load='1bn0' size='340' side='right'caption='[[1bn0]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1bn0]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BN0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BN0 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bn0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bn0 OCA], [https://pdbe.org/1bn0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bn0 RCSB], [https://www.ebi.ac.uk/pdbsum/1bn0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bn0 ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
An NMR-based structure is presented for a 20 mer hairpin model of the SL3 stem-loop from the HIV-1 packaging signal. The stem has an A-family structure. However, the GGAG tetraloop appears to be flexible with the second (G10) and fourth (G12) bases extruded from the normal stacking arrangement. The A-base (A11) occupies a cavity large enough for it to jump rapidly between stacking upon G9 (in the loop) and G13 (from the base-pair adjacent to the loop). The H-bonding loci of G10, A11, and G12 are unoccupied in the free RNA structure. The loop should be easily adaptable to binding by the HIV-1 nucleocapsid protein or loop receptors.
An NMR-based structure is presented for a 20 mer hairpin model of the SL3 stem-loop from the HIV-1 packaging signal. The stem has an A-family structure. However, the GGAG tetraloop appears to be flexible with the second (G10) and fourth (G12) bases extruded from the normal stacking arrangement. The A-base (A11) occupies a cavity large enough for it to jump rapidly between stacking upon G9 (in the loop) and G13 (from the base-pair adjacent to the loop). The H-bonding loci of G10, A11, and G12 are unoccupied in the free RNA structure. The loop should be easily adaptable to binding by the HIV-1 nucleocapsid protein or loop receptors.


==About this Structure==
Three-dimensional folding of an RNA hairpin required for packaging HIV-1.,Pappalardo L, Kerwood DJ, Pelczer I, Borer PN J Mol Biol. 1998 Oct 2;282(4):801-18. PMID:9743628<ref>PMID:9743628</ref>
1BN0 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BN0 OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
Three-dimensional folding of an RNA hairpin required for packaging HIV-1., Pappalardo L, Kerwood DJ, Pelczer I, Borer PN, J Mol Biol. 1998 Oct 2;282(4):801-18. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9743628 9743628]
</div>
[[Category: Protein complex]]
<div class="pdbe-citations 1bn0" style="background-color:#fffaf0;"></div>
[[Category: Borer, P N.]]
== References ==
[[Category: Kerwood, D J.]]
<references/>
[[Category: Pappalardo, L.]]
__TOC__
[[Category: Pelczer, I.]]
</StructureSection>
[[Category: hiv-1]]
[[Category: Large Structures]]
[[Category: nmr]]
[[Category: Borer PN]]
[[Category: packaging]]
[[Category: Kerwood DJ]]
[[Category: ribonucleic acid]]
[[Category: Pappalardo L]]
[[Category: rna]]
[[Category: Pelczer I]]
[[Category: tetraloop]]
 
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