1j9c: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
m Protected "1j9c" [edit=sysop:move=sysop]
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
No edit summary
 
(10 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:1j9c.png|left|200px]]


{{STRUCTURE_1j9c|  PDB=1j9c  |  SCENE=  }}
==Crystal Structure of tissue factor-factor VIIa complex==
 
<StructureSection load='1j9c' size='340' side='right'caption='[[1j9c]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
===Crystal Structure of tissue factor-factor VIIa complex===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1j9c]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J9C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J9C FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0Z6:D-PHENYLALANYL-N-[(2S,3S)-6-{[AMINO(IMINIO)METHYL]AMINO}-1-CHLORO-2-HYDROXYHEXAN-3-YL]-L-PHENYLALANINAMIDE'>0Z6</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
[[1j9c]] is a 3 chain structure of [[Factor VIIa]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J9C OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j9c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j9c OCA], [https://pdbe.org/1j9c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j9c RCSB], [https://www.ebi.ac.uk/pdbsum/1j9c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j9c ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TF_HUMAN TF_HUMAN] Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.<ref>PMID:12652293</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j9/1j9c_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1j9c ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Factor VIIa|Factor VIIa]]
*[[Factor VIIa 3D structures|Factor VIIa 3D structures]]
*[[Tissue factor|Tissue factor]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Edgington, T S.]]
[[Category: Large Structures]]
[[Category: Huang, M.]]
[[Category: Edgington TS]]
[[Category: Ruf, W.]]
[[Category: Huang M]]
[[Category: Wilson, I A.]]
[[Category: Ruf W]]
[[Category: Blood clotting]]
[[Category: Wilson IA]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Mobile loop]]
Retrieved from "https://proteopedia.org/1j9c"