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[[Image:3goc.png|left|200px]]


{{STRUCTURE_3goc|  PDB=3goc  |  SCENE=  }}
==Crystal structure of the Endonuclease V (SAV1684) from Streptomyces avermitilis. Northeast Structural Genomics Consortium Target SvR196==
 
<StructureSection load='3goc' size='340' side='right'caption='[[3goc]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
===Crystal structure of the Endonuclease V (SAV1684) from Streptomyces avermitilis. Northeast Structural Genomics Consortium Target SvR196===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3goc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_avermitilis_MA-4680_=_NBRC_14893 Streptomyces avermitilis MA-4680 = NBRC 14893]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GOC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GOC FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=YES:3-(2-HYDROXYETHYL)-2,2-BIS(HYDROXYMETHYL)PENTANE-1,5-DIOL'>YES</scene></td></tr>
[[3goc]] is a 2 chain structure of [[Endonuclease]] with sequence from [http://en.wikipedia.org/wiki/Streptomyces_avermitilis Streptomyces avermitilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GOC OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3goc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3goc OCA], [https://pdbe.org/3goc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3goc RCSB], [https://www.ebi.ac.uk/pdbsum/3goc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3goc ProSAT], [https://www.topsan.org/Proteins/NESGC/3goc TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NFI_STRAW NFI_STRAW] DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA (By similarity).[HAMAP-Rule:MF_00801]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/go/3goc_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3goc ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Endonuclease|Endonuclease]]
*[[Endonuclease 3D structures|Endonuclease 3D structures]]
[[Category: Deoxyribonuclease V]]
__TOC__
[[Category: Streptomyces avermitilis]]
</StructureSection>
[[Category: Abashidze, M.]]
[[Category: Large Structures]]
[[Category: Acton, T B.]]
[[Category: Streptomyces avermitilis MA-4680 = NBRC 14893]]
[[Category: Chen, C X.]]
[[Category: Abashidze M]]
[[Category: Cunningham, K.]]
[[Category: Acton TB]]
[[Category: Everett, J K.]]
[[Category: Chen CX]]
[[Category: Fang, F.]]
[[Category: Cunningham K]]
[[Category: Forouhar, F.]]
[[Category: Everett JK]]
[[Category: Hunt, J F.]]
[[Category: Fang F]]
[[Category: Hussain, M.]]
[[Category: Forouhar F]]
[[Category: Ma, L.]]
[[Category: Hunt JF]]
[[Category: Montelione, G T.]]
[[Category: Hussain M]]
[[Category: NESG, Northeast Structural Genomics Consortium.]]
[[Category: Ma L]]
[[Category: Nair, R.]]
[[Category: Montelione GT]]
[[Category: Owens, L.]]
[[Category: Nair R]]
[[Category: Rost, B.]]
[[Category: Owens L]]
[[Category: Seetharaman, J.]]
[[Category: Rost B]]
[[Category: Tong, L.]]
[[Category: Seetharaman J]]
[[Category: Xiao, R.]]
[[Category: Tong L]]
[[Category: Alpha-beta protein]]
[[Category: Xiao R]]
[[Category: Dna damage]]
[[Category: Dna repair]]
[[Category: Endonuclease]]
[[Category: Hydrolase]]
[[Category: Magnesium]]
[[Category: Nesg]]
[[Category: Northeast structural genomics consortium]]
[[Category: Nuclease]]
[[Category: Protein structure initiative]]
[[Category: Psi-2]]
[[Category: Structural genomic]]
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