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[[Image:1hio.png|left|200px]]


{{STRUCTURE_1hio|  PDB=1hio  |  SCENE=  }}
==HISTONE OCTAMER (CHICKEN), CHROMOSOMAL PROTEIN, ALPHA CARBONS ONLY==
 
<StructureSection load='1hio' size='340' side='right'caption='[[1hio]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
===HISTONE OCTAMER (CHICKEN), CHROMOSOMAL PROTEIN, ALPHA CARBONS ONLY===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1hio]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HIO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HIO FirstGlance]. <br>
{{ABSTRACT_PUBMED_1946434}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hio OCA], [https://pdbe.org/1hio PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hio RCSB], [https://www.ebi.ac.uk/pdbsum/1hio PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hio ProSAT]</span></td></tr>
==About this Structure==
</table>
[[1hio]] is a 4 chain structure of [[Histone]] with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HIO OCA].  
== Function ==
[https://www.uniprot.org/uniprot/H2A4_CHICK H2A4_CHICK] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hi/1hio_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hio ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Histone|Histone]]
*[[Histone 3D structures|Histone 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:001946434</ref><ref group="xtra">PMID:018160966</ref><references group="xtra"/>
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
[[Category: Arents, G.]]
[[Category: Large Structures]]
[[Category: Moudrianakis, E N.]]
[[Category: Arents G]]
[[Category: Chromosomal protein]]
[[Category: Moudrianakis EN]]
[[Category: Histone]]
[[Category: Nucleosome core]]
Retrieved from "https://proteopedia.org/1hio"