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[[Image:2d9f.png|left|200px]]


{{STRUCTURE_2d9f|  PDB=2d9f  |  SCENE=  }}
==Solution structure of RUH-047, an FKBP domain from human cDNA==
 
<StructureSection load='2d9f' size='340' side='right'caption='[[2d9f]]' scene=''>
===Solution structure of RUH-047, an FKBP domain from human cDNA===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2d9f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D9F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D9F FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d9f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d9f OCA], [https://pdbe.org/2d9f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d9f RCSB], [https://www.ebi.ac.uk/pdbsum/2d9f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d9f ProSAT], [https://www.topsan.org/Proteins/RSGI/2d9f TOPSAN]</span></td></tr>
[[2d9f]] is a 1 chain structure of [[FK506 binding protein]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D9F OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/FKBP8_HUMAN FKBP8_HUMAN] Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.<ref>PMID:12510191</ref> <ref>PMID:16176796</ref> <ref>PMID:15757646</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d9/2d9f_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2d9f ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[FK506 binding protein|FK506 binding protein]]
*[[FKBP 3D structures|FKBP 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Hirota, H.]]
[[Category: Large Structures]]
[[Category: Kigawa, T.]]
[[Category: Hirota H]]
[[Category: Koshiba, S.]]
[[Category: Kigawa T]]
[[Category: Momen, A Z.M Ruhul.]]
[[Category: Koshiba S]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Ruhul Momen AZM]]
[[Category: Yokoyama, S.]]
[[Category: Yokoyama S]]
[[Category: Fk506 binding protein]]
[[Category: Fkbp]]
[[Category: Isomerase]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Rapamycin]]
[[Category: Riken structural genomics/proteomics initiative]]
[[Category: Rsgi]]
[[Category: Structural genomic]]
Retrieved from "https://proteopedia.org/2d9f"