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[[Image:1u55.png|left|200px]]


{{STRUCTURE_1u55| PDB=1u55 | SCENE= }}
==Crystal structure of an oxygen binding H-NOX domain related to soluble guanylate cyclases (oxygen complex)==
<StructureSection load='1u55' size='340' side='right'caption='[[1u55]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1u55]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caldanaerobacter_subterraneus_subsp._tengcongensis Caldanaerobacter subterraneus subsp. tengcongensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U55 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U55 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.77&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=OXY:OXYGEN+MOLECULE'>OXY</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u55 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u55 OCA], [https://pdbe.org/1u55 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u55 RCSB], [https://www.ebi.ac.uk/pdbsum/1u55 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u55 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q8RBX6_CALS4 Q8RBX6_CALS4]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u5/1u55_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u55 ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Soluble guanylate cyclases are nitric oxide-responsive signaling proteins in which the nitric oxide sensor is a heme-binding domain of unknown structure that we have termed the heme-NO and oxygen binding (H-NOX) domain. H-NOX domains are also found in bacteria, either as isolated domains, or are fused through a membrane-spanning region to methyl-accepting chemotaxis proteins. We have determined the crystal structure of an oxygen-binding H-NOX domain of one such signaling protein from the obligate anaerobe Thermoanaerobacter tengcongensis at 1.77-angstroms resolution, revealing a protein fold unrelated to known structures. Particularly striking is the structure of the protoporphyrin IX group, which is distorted from planarity to an extent not seen before in protein-bound heme groups. Comparison of the structure of the H-NOX domain in two different crystal forms suggests a mechanism whereby alteration in the degree of distortion of the heme group is coupled to changes on the molecular surface of the H-NOX domain and potentially to changes in intermolecular interactions.


===Crystal structure of an oxygen binding H-NOX domain related to soluble guanylate cyclases (oxygen complex)===
Crystal structure of an oxygen-binding heme domain related to soluble guanylate cyclases.,Pellicena P, Karow DS, Boon EM, Marletta MA, Kuriyan J Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):12854-9. Epub 2004 Aug 23. PMID:15326296<ref>PMID:15326296</ref>


{{ABSTRACT_PUBMED_15326296}}
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
==About this Structure==
<div class="pdbe-citations 1u55" style="background-color:#fffaf0;"></div>
[[1u55]] is a 2 chain structure of [[Methyl-accepting chemotaxis protein]] with sequence from [http://en.wikipedia.org/wiki/Caldanaerobacter_subterraneus_subsp._tengcongensis Caldanaerobacter subterraneus subsp. tengcongensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U55 OCA].


==See Also==
==See Also==
*[[Chemotaxis protein 3D structures|Chemotaxis protein 3D structures]]
*[[Methyl-accepting chemotaxis protein|Methyl-accepting chemotaxis protein]]
*[[Methyl-accepting chemotaxis protein|Methyl-accepting chemotaxis protein]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:015326296</ref><ref group="xtra">PMID:020459051</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Caldanaerobacter subterraneus subsp. tengcongensis]]
[[Category: Caldanaerobacter subterraneus subsp. tengcongensis]]
[[Category: Boon, E M.]]
[[Category: Large Structures]]
[[Category: Karow, D S.]]
[[Category: Boon EM]]
[[Category: Kuriyan, J.]]
[[Category: Karow DS]]
[[Category: Marletta, M A.]]
[[Category: Kuriyan J]]
[[Category: Pellicena, P.]]
[[Category: Marletta MA]]
[[Category: Chemotaxis]]
[[Category: Pellicena P]]
[[Category: H-nox domain]]
[[Category: Heme]]
[[Category: Oxygen sensor]]
[[Category: Signal transduction]]
[[Category: Signaling protein]]
Retrieved from "https://proteopedia.org/1u55"