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[[Image:1u73.png|left|200px]]


{{STRUCTURE_1u73|  PDB=1u73  |  SCENE=  }}
==Crystal structure of a Dimeric Acidic Platelet Aggregation Inhibitor and Hypotensive Phospholipase A2 from Bothrops jararacussu==
 
<StructureSection load='1u73' size='340' side='right'caption='[[1u73]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
===Crystal structure of a Dimeric Acidic Platelet Aggregation Inhibitor and Hypotensive Phospholipase A2 from Bothrops jararacussu===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1u73]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bothrops_jararacussu Bothrops jararacussu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U73 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U73 FirstGlance]. <br>
{{ABSTRACT_PUBMED_15351695}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u73 OCA], [https://pdbe.org/1u73 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u73 RCSB], [https://www.ebi.ac.uk/pdbsum/1u73 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u73 ProSAT]</span></td></tr>
==About this Structure==
</table>
[[1u73]] is a 2 chain structure of [[Phospholipase A2]] with sequence from [http://en.wikipedia.org/wiki/Bothrops_jararacussu Bothrops jararacussu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U73 OCA].  
== Function ==
[https://www.uniprot.org/uniprot/PA2A_BOTJR PA2A_BOTJR] Snake venom phospholipase A2 (PLA2) that induces edema (activity that is inhibited by EDTA and dexamethasone), inhibits phospholipid-dependent collagen/ADP-induced platelet aggregation, possess hypotensive as well as anticoagulant activities. In addition, this enzyme shows bactericidal activity against E.coli and S.aureus. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:12167491</ref> <ref>PMID:15214498</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u7/1u73_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u73 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Phospholipase A2|Phospholipase A2]]
*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:015351695</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Bothrops jararacussu]]
[[Category: Bothrops jararacussu]]
[[Category: Arni, R K.]]
[[Category: Large Structures]]
[[Category: Fontes, M R.]]
[[Category: Arni RK]]
[[Category: Magro, A J.]]
[[Category: Fontes MR]]
[[Category: Murakami, M T.]]
[[Category: Magro AJ]]
[[Category: Soares, A M.]]
[[Category: Murakami MT]]
[[Category: Acidic phospholipase a2]]
[[Category: Soares AM]]
[[Category: Bothrops jararacussu venom]]
[[Category: Dimeric]]
[[Category: Hydrolase]]
[[Category: Oligomeric state]]
[[Category: Platelet aggregation and hypotensive effect]]
Retrieved from "https://proteopedia.org/1u73"