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[[Image:1sg0.png|left|200px]]


{{STRUCTURE_1sg0|  PDB=1sg0  |  SCENE=  }}
==Crystal structure analysis of QR2 in complex with resveratrol==
 
<StructureSection load='1sg0' size='340' side='right'caption='[[1sg0]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
===Crystal structure analysis of QR2 in complex with resveratrol===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1sg0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SG0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SG0 FirstGlance]. <br>
{{ABSTRACT_PUBMED_15350128}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=STL:RESVERATROL'>STL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sg0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sg0 OCA], [https://pdbe.org/1sg0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sg0 RCSB], [https://www.ebi.ac.uk/pdbsum/1sg0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sg0 ProSAT]</span></td></tr>
[[1sg0]] is a 2 chain structure of [[Quinone reductase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SG0 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sg/1sg0_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sg0 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Quinone reductase|Quinone reductase]]
*[[Quinone reductase 3D structures|Quinone reductase 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:015350128</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Boyd, M.]]
[[Category: Large Structures]]
[[Category: Buryanovskyy, L.]]
[[Category: Boyd M]]
[[Category: Fu, Y.]]
[[Category: Buryanovskyy L]]
[[Category: Ma, Y.]]
[[Category: Fu Y]]
[[Category: Tsieh, T C.]]
[[Category: Ma Y]]
[[Category: Wu, J M.]]
[[Category: Tsieh TC]]
[[Category: Zhang, Z.]]
[[Category: Wu JM]]
[[Category: Oxidoreductase]]
[[Category: Zhang Z]]
[[Category: Quinone reductase 2]]
[[Category: Resveratrol]]
Retrieved from "https://proteopedia.org/1sg0"