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[[Image:4ame.png|left|200px]]


{{STRUCTURE_4ame|  PDB=4ame  |  SCENE=  }}
==TYPE III ANTIFREEZE PROTEIN ISOFORM HPLC 12 T18A==
 
<StructureSection load='4ame' size='340' side='right'caption='[[4ame]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
===TYPE III ANTIFREEZE PROTEIN ISOFORM HPLC 12 T18A===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4ame]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Zoarces_americanus Zoarces americanus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AME OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AME FirstGlance]. <br>
{{ABSTRACT_PUBMED_10207002}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ame FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ame OCA], [https://pdbe.org/4ame PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ame RCSB], [https://www.ebi.ac.uk/pdbsum/4ame PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ame ProSAT]</span></td></tr>
==About this Structure==
</table>
[[4ame]] is a 1 chain structure of [[Antifreeze protein]] with sequence from [http://en.wikipedia.org/wiki/Zoarces_americanus Zoarces americanus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AME OCA].  
== Function ==
[https://www.uniprot.org/uniprot/ANP12_ZOAAM ANP12_ZOAAM] Contributes to protect fish blood from freezing at subzero sea water temperatures. Lowers the blood freezing point. Binds to nascent ice crystals and prevents further growth.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/am/4ame_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=4ame ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Antifreeze protein|Antifreeze protein]]
*[[Antifreeze protein 3D structures|Antifreeze protein 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:010207002</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: Zoarces americanus]]
[[Category: Zoarces americanus]]
[[Category: Baardsnes, J.]]
[[Category: Baardsnes J]]
[[Category: Davies, P L.]]
[[Category: Davies PL]]
[[Category: Deluca, C I.]]
[[Category: Deluca CI]]
[[Category: Graether, S P.]]
[[Category: Graether SP]]
[[Category: Hill, G A.]]
[[Category: Hill GA]]
[[Category: Jia, Z.]]
[[Category: Jia Z]]
[[Category: Antifreeze protein]]
[[Category: Ice binding protein]]
[[Category: Mutant]]
[[Category: Thermal hysteresis protein]]
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