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[[Image:2xsn.png|left|200px]]


{{STRUCTURE_2xsn|  PDB=2xsn  |  SCENE= }}
==Crystal Structure of Human Tyrosine Hydroxylase Catalytic Domain==
 
<StructureSection load='2xsn' size='340' side='right'caption='[[2xsn]], [[Resolution|resolution]] 2.68&Aring;' scene=''>
===CRYSTAL STRUCTURE OF HUMAN TYROSINE HYDROXYLASE CATALYTIC DOMAIN===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2xsn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XSN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XSN FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.68&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[2xsn]] is a 4 chain structure of [[Tyrosine hydroxylase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XSN OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xsn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xsn OCA], [https://pdbe.org/2xsn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xsn RCSB], [https://www.ebi.ac.uk/pdbsum/2xsn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xsn ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/TY3H_HUMAN TY3H_HUMAN] Autosomal recessive dopa-responsive dystonia. The disease is caused by mutations affecting the gene represented in this entry.  May play a role in the pathogenesis of Parkinson disease (PD). A genome-wide copy number variation analysis has identified a 34 kilobase deletion over the TH gene in a PD patient but not in any controls.<ref>PMID:20809526</ref>
== Function ==
[https://www.uniprot.org/uniprot/TY3H_HUMAN TY3H_HUMAN] Plays an important role in the physiology of adrenergic neurons.


==See Also==
==See Also==
*[[Tyrosine hydroxylase|Tyrosine hydroxylase]]
*[[Hydroxylases 3D structures|Hydroxylases 3D structures]]
*[[Monooxygenase 3D structures|Monooxygenase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Tyrosine 3-monooxygenase]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H.]]
[[Category: Arrowsmith CH]]
[[Category: Bountra, C.]]
[[Category: Bountra C]]
[[Category: Cooper, C D.O.]]
[[Category: Cooper CDO]]
[[Category: Edwards, A M.]]
[[Category: Edwards AM]]
[[Category: Gileadi, O.]]
[[Category: Gileadi O]]
[[Category: Kavanagh, K L.]]
[[Category: Kavanagh KL]]
[[Category: Knapp, S.]]
[[Category: Knapp S]]
[[Category: Krysztofinska, E.]]
[[Category: Krysztofinska E]]
[[Category: Muniz, J R.C.]]
[[Category: Muniz JRC]]
[[Category: Oppermann, U.]]
[[Category: Oppermann U]]
[[Category: Vondelft, F.]]
[[Category: Weigelt J]]
[[Category: Weigelt, J.]]
[[Category: Yue WW]]
[[Category: Yue, W W.]]
[[Category: Von Delft F]]
[[Category: Oxidoreductase]]
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