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[[Image:2vsw.png|left|200px]]


{{STRUCTURE_2vsw|  PDB=2vsw  |  SCENE= }}
==The structure of the rhodanese domain of the human dual specificity phosphatase 16==
 
<StructureSection load='2vsw' size='340' side='right'caption='[[2vsw]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
===THE STRUCTURE OF THE RHODANESE DOMAIN OF THE HUMAN DUAL SPECIFICITY PHOSPHATASE 16===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2vsw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VSW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VSW FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vsw OCA], [https://pdbe.org/2vsw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vsw RCSB], [https://www.ebi.ac.uk/pdbsum/2vsw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vsw ProSAT]</span></td></tr>
[[2vsw]] is a 2 chain structure of [[MAP kinase phosphatase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VSW OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/DUS16_HUMAN DUS16_HUMAN] Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2.<ref>PMID:11489891</ref> <ref>PMID:15888437</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vs/2vsw_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vsw ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Dual specificity phosphatase 3D structures|Dual specificity phosphatase 3D structures]]
*[[MAP kinase phosphatase|MAP kinase phosphatase]]
*[[MAP kinase phosphatase|MAP kinase phosphatase]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H.]]
[[Category: Large Structures]]
[[Category: Barr, A.]]
[[Category: Arrowsmith CH]]
[[Category: Bishop, S.]]
[[Category: Barr A]]
[[Category: Bountra, C.]]
[[Category: Bishop S]]
[[Category: Bray, J.]]
[[Category: Bountra C]]
[[Category: Burgess-Brown, N.]]
[[Category: Bray J]]
[[Category: Edwards, A M.]]
[[Category: Burgess-Brown N]]
[[Category: Elkins, J.]]
[[Category: Edwards AM]]
[[Category: Gileadi, O.]]
[[Category: Elkins J]]
[[Category: Knapp, S.]]
[[Category: Gileadi O]]
[[Category: Murray, J W.]]
[[Category: Knapp S]]
[[Category: Pantic, N.]]
[[Category: Murray JW]]
[[Category: Phillips, C.]]
[[Category: Pantic N]]
[[Category: Pike, A C.W.]]
[[Category: Phillips C]]
[[Category: Roos, A.]]
[[Category: Pike ACW]]
[[Category: Savitsky, P.]]
[[Category: Roos A]]
[[Category: Vondelft, F.]]
[[Category: Savitsky P]]
[[Category: Wang, J.]]
[[Category: Wang J]]
[[Category: Wickstroem, M.]]
[[Category: Wickstroem M]]
[[Category: Casp8]]
[[Category: Von Delft F]]
[[Category: Dual specificity phosphatase]]
[[Category: Hydrolase]]
[[Category: Nucleus]]
[[Category: Protein phosphatase]]
[[Category: Rhodanese domain]]
Retrieved from "https://proteopedia.org/2vsw"