1glo: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
No edit summary
 
(10 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:1glo.png|left|200px]]


{{STRUCTURE_1glo| PDB=1glo | SCENE= }}
==Crystal Structure of Cys25Ser mutant of human cathepsin S==
<StructureSection load='1glo' size='340' side='right'caption='[[1glo]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1glo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GLO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GLO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1glo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1glo OCA], [https://pdbe.org/1glo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1glo RCSB], [https://www.ebi.ac.uk/pdbsum/1glo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1glo ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CATS_HUMAN CATS_HUMAN] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gl/1glo_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1glo ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Cathepsin S (EC 3.4.22.27), a cysteine proteinase of the papain superfamily, plays a critical role in the generation of a major histocompatibility complex (MHC) class II restricted T-cell response by antigen-presenting cells. Therefore, selective inhibition of this enzyme may be useful in modulating class II restricted T-cell responses in immune-related disorders such as rheumatoid arthritis, multiple sclerosis and extrinsic asthma. The three-dimensional structure at 2.2 A resolution of the active-site Cys25--&gt;Ser mutant presented here in an unliganded state provides further insight useful for the design of selective enzyme inhibitors.


===CRYSTAL STRUCTURE OF CYS25SER MUTANT OF HUMAN CATHEPSIN S===
Structure of a Cys25--&gt;Ser mutant of human cathepsin S.,Turkenburg JP, Lamers MB, Brzozowski AM, Wright LM, Hubbard RE, Sturt SL, Williams DH Acta Crystallogr D Biol Crystallogr. 2002 Mar;58(Pt 3):451-5. Epub 2002, Feb 21. PMID:11856830<ref>PMID:11856830</ref>


{{ABSTRACT_PUBMED_11856830}}
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
==About this Structure==
<div class="pdbe-citations 1glo" style="background-color:#fffaf0;"></div>
[[1glo]] is a 1 chain structure of [[Cathepsin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GLO OCA].


==See Also==
==See Also==
*[[Cathepsin|Cathepsin]]
*[[Cathepsin 3D structures|Cathepsin 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:011856830</ref><references group="xtra"/>
__TOC__
[[Category: Cathepsin S]]
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Brzozowski, A M.]]
[[Category: Large Structures]]
[[Category: Hubbard, R E.]]
[[Category: Brzozowski AM]]
[[Category: Lamers, M B.A C.]]
[[Category: Hubbard RE]]
[[Category: Sturt, S L.]]
[[Category: Lamers MBAC]]
[[Category: Turkenburg, J P.]]
[[Category: Sturt SL]]
[[Category: Williams, D H.]]
[[Category: Turkenburg JP]]
[[Category: Wright, L M.]]
[[Category: Williams DH]]
[[Category: Cathepsin s]]
[[Category: Wright LM]]
[[Category: Hydrolase]]
[[Category: Inhibitor]]
[[Category: Proteinase]]
[[Category: Thiol protea]]
Retrieved from "https://proteopedia.org/1glo"