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[[Image:1ds7.png|left|200px]]


{{STRUCTURE_1ds7|  PDB=1ds7  |  SCENE=  }}
==A MINOR FMN-DEPENDENT NITROREDUCTASE FROM ESCHERICHIA COLI B==
 
<StructureSection load='1ds7' size='340' side='right'caption='[[1ds7]], [[Resolution|resolution]] 2.06&Aring;' scene=''>
===A MINOR FMN-DEPENDENT NITROREDUCTASE FROM ESCHERICHIA COLI B===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1ds7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_B Escherichia coli B]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DS7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DS7 FirstGlance]. <br>
{{ABSTRACT_PUBMED_11020276}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.06&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ds7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ds7 OCA], [https://pdbe.org/1ds7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ds7 RCSB], [https://www.ebi.ac.uk/pdbsum/1ds7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ds7 ProSAT]</span></td></tr>
[[1ds7]] is a 2 chain structure of [[Nitroreductase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DS7 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/NFSB_ECOLI NFSB_ECOLI] Reduction of a variety of nitroaromatic compounds using NADH (and to lesser extent NADPH) as source of reducing equivalents; two electrons are transferred. Capable of reducing nitrofurazone, quinones and the anti-tumor agent CB1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide). The reduction of CB1954 results in the generation of cytotoxic species.<ref>PMID:15684426</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ds/1ds7_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ds7 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Nitroreductase|Nitroreductase]]
*[[Nitroreductase 3D structures|Nitroreductase 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:011020276</ref><references group="xtra"/>
__TOC__
[[Category: 6,7-dihydropteridine reductase]]
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli B]]
[[Category: Neidle, S.]]
[[Category: Large Structures]]
[[Category: Parkinson, G.]]
[[Category: Neidle S]]
[[Category: Skelly, J.]]
[[Category: Parkinson G]]
[[Category: Flavoprotein]]
[[Category: Skelly J]]
[[Category: Fmn]]
[[Category: Nitroreductase]]
[[Category: Oxidoreductase]]
Retrieved from "https://proteopedia.org/1ds7"