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[[Image:1mkh.png|left|200px]]


{{STRUCTURE_1mkh|  PDB=1mkh  |  SCENE=  }}
==C-terminal domain of methionyl-tRNA synthetase from Pyrococcus abyssi==
 
<StructureSection load='1mkh' size='340' side='right'caption='[[1mkh]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
===C-terminal domain of methionyl-tRNA synthetase from Pyrococcus abyssi===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1mkh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_abyssi Pyrococcus abyssi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MKH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MKH FirstGlance]. <br>
{{ABSTRACT_PUBMED_12390027}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.01&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mkh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mkh OCA], [https://pdbe.org/1mkh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mkh RCSB], [https://www.ebi.ac.uk/pdbsum/1mkh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mkh ProSAT]</span></td></tr>
==About this Structure==
</table>
[[1mkh]] is a 1 chain structure of [[Aminoacyl tRNA Synthetase]] with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_abyssi Pyrococcus abyssi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MKH OCA].  
== Function ==
[https://www.uniprot.org/uniprot/SYM_PYRAB SYM_PYRAB] Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mk/1mkh_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mkh ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Aminoacyl tRNA Synthetase|Aminoacyl tRNA Synthetase]]
*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:012390027</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: Methionine--tRNA ligase]]
[[Category: Pyrococcus abyssi]]
[[Category: Pyrococcus abyssi]]
[[Category: Blanquet, S.]]
[[Category: Blanquet S]]
[[Category: Crepin, T.]]
[[Category: Crepin T]]
[[Category: Mechulam, Y.]]
[[Category: Mechulam Y]]
[[Category: Schmitt, E.]]
[[Category: Schmitt E]]
[[Category: Beta barrel]]
[[Category: Dimerization domain]]
[[Category: Ligase]]
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